Combination chemotherapy

Details Combination chemotherapy Combination chemotherapy

1995-05-01

1997-05-27

Goldberg, Jerome D.

Drug, bio-affecting and body treating compositions

Inorganic active ingredient containing

Heavy metal or compound thereof

514283, A61K 3324, A61K 3144

Patent

active

056330162

ABSTRACT:
A pharmaceutical composition comprising a compound of the camptothecin analog class and a platinum coordination compound and a pharmaceutically acceptable carrier or diluent; a method of inhibiting the growth of tumor cells in a human afflicted therewith which comprises administering to such human an effective tumor cell growth inhibiting amount of such pharmaceutical composition; and a method of inhibiting the growth of tumor cells in a human afflicated therewith which comprises administering to such human an effective tumor cell growth inhibiting amount of the combination of a compound of the camptothecin analog class and a platinum coordination compound.

REFERENCES:
patent: 5004758 (1991-04-01), Boehm et al.
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Kano, et al., "Effects of CPT-11 in Combination With Other Anti-Cancer Agents in Culture", (1992), Int. J. Cancer, vol. 50, No. 4, pp. 604-610.
Furuta et al., "Combination Therapy of CPT-11, a Camptothecin Derivative With Various Antitumor Drugs Against L 1210 Leukemia", (1991), STN International, Karlsruhe, 18(3), pp. 393-402 Abstract Only.
Drewinko, et al., "Combination Chemotherapy In Vitro with Cis-dichlorodiammineplatinum(II)", (1976), Cancer Treat. Rep., vol. 60, No. 11, pp. 1619-1625.
Drewinko, et al., "Action of Cis-dichlorodiammineplatinum(II) (NCS-119875) at the Cellular Level", (1975), Cancer Chemother. Rep., vol. 59, No. 3, pp. 665-673.
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Abstract 00011628, Pharmaprojects, PJB Publications Ltd., Richmond, Surrey UK, Jun. 26, 1990.
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