Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2006-01-17
2006-01-17
Smith, Lynette R. F. (Department: 1645)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C536S023400, C536S023700, C514S04400A, C530S825000, C530S403000, C435S006120, C435S091100, C435S071100, C435S069100, C435S071200, C435S252300, C435S252800, C435S320100
Reexamination Certificate
active
06987176
ABSTRACT:
This invention comprises a recombinant protein comprising the maltose binding protein (MBP) ofEscherichia colifused to amino acids 5–337 of the FlaA flagellin ofCampylobacter coliVC167 which has provided evidence of immunogenicity and protective efficacy against challenge by a heterologous strain ofcampylobacter, Campylobacter jejuni81–176 in mammals. The invention further comprises a recombinant DNA construct encoding the immunodominant region (region I through III) of flagellin fromCampylobacterspp. for use as a component of a vaccine againstCampylobacterdiarrhea. The invention therefore represents an effective treatment againstCampylobacterbut avoids inducing the autoimmune Guillain Barre Syndrome (GBS), a post-infection polyneuropathy caused byCampylobactermolecular mimicry of human gangliosides which has hampered the development of vaccines heretofore.
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Burg Edward
Guerry Patricia
Lee Lanfong H.
Trust Trevor J.
Churilla Albert M.
Hemby, Jr. Joseph K.
Portner Ginny Allen
Smith Lynette R. F.
The United States of America as represented by the Secretary of
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