Combating bacteria with nitroimidazolyl-triazolo-pyridiazine com

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...

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424248, A01N 900, A01N 922

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active

039898326

ABSTRACT:
Nitroimidazolyl-s-triazolo[4,3-b]pyridazines of the formula: ##SPC1##
Wherein R is hydrogen or lower alkyl optionally substituted in the 2-position by hydroxyl or by lower acyloxy or lower alkoxy;
A is hydrogen, halogen, azido, cyano; lower alkyl, alkoxy, alkylthio, alkylsulfonyl, carboxyl; lower alkoxycarbonyl, lower alkoxycarbonimidoyl; or hydrazino, carbamoyl, amidino or a carboximidohydrazide group optionally substituted by one or two lower acyl, alkyl or cycloalkyl radicals; or
A is a radical of the formula: ##EQU1## wherein R.sub.1 and R.sub.2 are, individually, hydrogen or a number of organic radicals or, taken together, can be an alkylene bridge; and
R.sub.3 is hydrogen or lower alkyl; or, together with R.sub.2, R.sub.3 can form an alkylene bridge;
n is 0 or 1;
And the pharmaceutically compatible thereof, possess high in vivo effectiveness as antimicrobials.

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patent: 3686203 (1972-08-01), Somerset et al.
patent: 3720687 (1973-03-01), Kirby et al.
patent: 3721668 (1973-03-01), Rufer et al.
patent: 3723453 (1973-03-01), Gradnik et al.
patent: 3790592 (1974-02-01), Carson et al.

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