Column packing material

Stock material or miscellaneous articles – Coated or structually defined flake – particle – cell – strand,... – Particulate matter

Reexamination Certificate

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C427S221000, C427S302000, C427S314000

Reexamination Certificate

active

10710937

ABSTRACT:
A porous silica particle suitable can be used in zwitterionic high performance liquid chromatography. The particle comprises covalently bound zwitterionic groups grafted through a polymerization reaction. A hydrophilic column packing material suitable for use as a stationary phase in zwitterionic high performance liquid chromatography may comprise porous silica particles. The particles may comprise covalently bound zwitterionic groups. Methods for manufacturing and applying the silica particles exist.

REFERENCES:
patent: 5476660 (1995-12-01), Somasundaran et al.
patent: 5589069 (1996-12-01), Wenzhi
patent: 5645883 (1997-07-01), Russell et al.
patent: 6866793 (2005-03-01), Singh
patent: 6884345 (2005-04-01), Irgum et al.
patent: 2003/0168627 (2003-09-01), Singh et al.
Yu et al., “The Synthesis and Characterization of Chemically Bonded Silica-Based Zwitterion-Exchangers for HPLC”, Journal of Chromatographic Science, vol. 24, May 1986, 177-182.
Arasawa et al., “Grafting of zwitterion-type polymers onto silica gel surface and their properties”, Reactive and Functional Polmers 61 (2004) 153-161.

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