Colostral fractionation process

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Separation or purification

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C424S157100

Reexamination Certificate

active

07547770

ABSTRACT:
A method (100) and a system (200) for processing mammalian bodily fluids to isolate target peptides and proteins. The method can include the steps of passing a mammalian bodily fluid through at least one ion exchange column (204). The ion exchange column can include an anionic resin and/or a cationic resin. The ion exchange column can be selected to remove large particles at a first pH level selected to remove such large particles at a maximum fluid pressure of 30 pounds per square inch (psi), for example less than 10 psi. The large particles can be released from the ion exchange column with a rinse solution having a pH selected for releasing the large particles. The pH of the fluid then can be adjusted to be a value less than 5.0, and the fluid can be filtered with a microfilter or ultrafilter (210).

REFERENCES:
patent: 4091116 (1978-05-01), Edwards et al.
patent: 4497836 (1985-02-01), Marquardt et al.
patent: 4668771 (1987-05-01), Kawakami et al.
patent: 4689151 (1987-08-01), Kosikowski et al.
patent: 4997914 (1991-03-01), Kawakami et al.
patent: 5149647 (1992-09-01), Burling
patent: 5290685 (1994-03-01), Koide et al.
patent: 6010698 (2000-01-01), Kussendrager et al.
patent: 6096870 (2000-08-01), Mozaffar et al.
patent: 6139746 (2000-10-01), Kopf
patent: 6852700 (2005-02-01), Janusz et al.
patent: 6903068 (2005-06-01), Stanton et al.
patent: 2002/0127279 (2002-09-01), Matthews
patent: 2004/0266681 (2004-12-01), Boldogh et al.
patent: WO 98/14473 (1998-04-01), None
patent: WO 0075173 (2000-12-01), None
Shing et al., “Purification of polypeptide growth factors from milk”, Methods in Enzymology 146: 42-48 (1987).
Ion Exchange Chromatography, principles and methods, Chpt. 7, 29-38 (1980) (Pharmacia Fine Chemicals).
Cechova, D., “Trypsin inhibitor from cow colostrum”, Methods Enzymology 45: 806-813 (1976).
Riediker et al., “Analysis of beta-lactam antibiotics in incurred raw milk by rapid test methods and liquid chromatography coupled with electrospray ionization tandem mass spectrometry”, J. Agric. Food Chem. 49: 4171-4176 (2001).
Janusz et al., “Immunoglobulins of colostrum”, Achivum Immunologiae Et Therapiae Experimentalis 21: 435-444 (1973).
Takayama et al, Factors in Bovine Colostrum that Enhance the Migration of Human Fibroblasts in Type I Collagen Gels, Biosci. Biotech. Biochem. 2001 vol. 65, No. 12, pp. 2776-2779.
Janusz et al., Chemical and Physical Characterization of a Proline-Rich Polypeptide from Sheep Colostrum, Biochem. J. 1981 vol. 199, pp. 9-15.
Kruzel et al., The Alcohol-Induced Conformational Changes in Casein Micelles: A New Challenge for the Purification of Colostrinin, The Protein Jour., 2004 V 23 No. 2, pp. 127-133.
Inglot, et al.: “Colostrinine: a proline-rich polypeptide from ovine colostrum is a modest cytokine inducer in human leukocytes,” Archivum Immunologiae et Therapiae Experimentalis, 1996, vol. 44, pp. 215-224.
Staroscik, Krystyna et al.:“Immunologically active nonapeptide fragment of a proline-rich polypeptide from ovine colostrum: amino acid sequence and immunoregulatory properties,” Molecular Immunology, 1983, vol. 20 (12), pp. 1277-1282.
Uruakpa, et al.: “Colostrum and its benefits: a review,” Nutrition Research, 2002, vol. 22, pp. 755-767.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Colostral fractionation process does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Colostral fractionation process, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Colostral fractionation process will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-4148255

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.