Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1993-04-02
1995-07-25
Parr, Margaret
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
4353201, 435219, 435 23, 435 24, C12Q 137
Patent
active
054361311
ABSTRACT:
A chromogenic assay is described for the identification and isolation of drug-resistant HIV protease mutants. Coversely, the assay is useful to screen for new inhibitors of HIV protease, e.g., inhibitors not affected by drug-resistance of the HIV protease. This color screening assay contains a vector comprising a regulatable promoter which controls the transcription of two adjacent structural sequences, one sequence coding for HIV protease or mutant thereof, the other sequence coding for beta-galactosidase with an amino acid substrate insert cleavable by HIV protease. A library of HIV proteases is also described and is isolated in the form of a collection of such vectors, which is a color screen vector library.
REFERENCES:
DBA Abstract, Accession No. 90-03222, Wolf, German Patent No. De 3,819,846.
Kohl et al., Proc. Natl. Acad. Sci. USA, vol. 85, (Jul. 1988), pp. 4686-4690.
Condra Jon H.
Gotlib Leah
Graham Donald J.
Caruso Charles M.
Houtteman Scott W.
Merck & Co. , Inc.
Meredith Roy D.
Parr Margaret
LandOfFree
Color screening assay for identifying inhibitor resistant HIV pr does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Color screening assay for identifying inhibitor resistant HIV pr, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Color screening assay for identifying inhibitor resistant HIV pr will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-739011