Color control & stability in acetaminophen

Organic compounds -- part of the class 532-570 series – Organic compounds – Amino nitrogen containing

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564142, 564144, 564223, 564 2, C07C23305

Patent

active

053997603

ABSTRACT:
A method is provided for purifying crude N-acetyl-para-aminophenol (APAP) containing color bodies or their precursors, the method comprising: a) forming a solution of the crude APAP; and b) subsequently contacting the solution with substoichiometric quantifies of an acetylating agent for a sufficient period of time to convert said color bodies or their precursors to substantially non-color bodies/stable, colorless substances; said quantities of acetylating agent provided is such that substantially none of the APAP is converted to other compounds.

REFERENCES:
patent: 3113150 (1963-12-01), Young
patent: 3748358 (1973-07-01), Baron
patent: 4524217 (1985-06-01), Davenport et al.
patent: 4607125 (1986-08-01), Mott
patent: 5155269 (1992-10-01), Dunn et al.
Merck Index, 10th Edition, 5135, p. 761, 1983.

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