Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1997-08-07
1999-03-30
Rose, Shep K.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
424469, 424474, 424482, 424486, A61K 902, A61K 932, A61K 31465, A61K 3178
Patent
active
058890289
ABSTRACT:
A method is provided to treat inflammatory bowel disease by locally administering to the colon an effective amount of nicotine or a pharmaceutically acceptable salt thereof, preferably via formulations adapted for delayed oral release or rectal administration. Further provided is a novel formulation for the oral administration of nicotine comprising a polyacrylic polymer complexed with nicotine.
REFERENCES:
patent: 3877468 (1975-04-01), Lichtneckert et al.
patent: 3901248 (1975-08-01), Lichtneckert et al.
patent: 4855142 (1989-08-01), Fankhauser et al.
patent: 5069904 (1991-12-01), Masterson
patent: 5362496 (1994-11-01), Baker et al.
patent: 5502080 (1996-03-01), Hitzig
patent: 5512306 (1996-04-01), Carlsson et al.
patent: 5549906 (1996-08-01), Santus
patent: 5593684 (1997-01-01), Baker et al.
patent: 5604231 (1997-02-01), Smith et al.
patent: 5662920 (1997-09-01), Santus
patent: 5721257 (1998-02-01), Baker et al.
patent: 5783207 (1998-07-01), Stanley et al.
Srivastava, E. D., et al, Eur. J. Gastroenterol., 3, 815-818 (1991).
Thomas, G. A. O., et al, Eur. J. Gastroenterol., 8, 769-776 (1996).
Lichtiger, S., et al, N. Engl. J. Med. 330, No. 26, 1841-1845 (Jun. 30, 1994).
Sandborn, W. J., et al, Gastroenterology, 108, 1429-1435 (1994).
Thomas, G. A. O., et al, N. Engl. J. Med., 332, No. 15, 988-992 (Apr. 19, 1995).
Lichtiger, S., et al, Gastroenterology, vol. 104, No. 4, Part 2, p. A732 AGA Abstracts (Apr. 1993).
Pullan, R. D., et al, N. Engl. J. Med., 330, No. 12, 811-815 (Mar. 24, 1994).
Zins, B. J., J. Clin. Pharmacol., 37, 426-436 (1997).
Sandborn, W. J., et al., "Transdermal Nicotine for Mildly to Moderately Active Ulcerative Colitis: A Randomized, Double-Blind Study, Placebo-Controlled Trial", presented at the annual meeting of the American Gastroenterology Association, May 20-22, 1996, San Francisco.
Sandborn, W. J., et al., Annals of Internal Medicine, vol. 126, No. 5, pp. 364-371 (Mar. 1997).
Cecil Textbook of Medicine, Wyngaarden, et al., eds., 19th edition, pp. 699-708, 1992, W. B. Saunders Company, Philadelphia.
Greenberg, G. R., et al., N. Eng. J. Med., vol. 331, No. 13, pp. 836-841 (Sep. 1994).
Anonymous, "Rectal Topical Corticosteroid Preparations", Drug and Therapeutics Bulletin 29, Publ. Consumer's Association, London, pp. 66-68 (1991).
Zins, B. J., et al., Gastroenterology, vol. 110, No. 4, p. A1054 (Apr. 1996).
Danish Budesonide Study Group, J. Gastroent., 1991, pp. 1225-1230.
Winder, T. A., et al., Scand. J. Gastroent. 28(8), pp. 701-704 (1993)--abstract only.
Handbook of Pharmaceutical Excipients, 2nd edition, p. 363.
Evans Brian Kenneth
Rhodes John
Rhodes Peter
Sandborn William
Mayo Foundation for Medical Education and Research
Rose Shep K.
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