Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Tablets – lozenges – or pills
Patent
1996-09-20
2000-03-21
Kulkosky, Peter F.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Tablets, lozenges, or pills
424472, A61K 924
Patent
active
060399759
ABSTRACT:
A novel delivery system for targeting drugs to the colon is herein described. The system is a tablet comprised of three parts: 1) an outer enteric coating, 2) an inner semi-permeable polymer membrane containing a plasticizer and 3) a central core comprising swelling excipients and an active ingredient. The novel dosage form described herein will release the drug consistently in the colon by a time-dependent explosion mechanism.
This delivery system is particularly suitable for delivering viral protease inhibitors to the colon.
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Phuapradit Wantanee
Railkar Aruna M.
Shah Navnit Hargovindas
Buchholz Briana C.
Epstein William H.
Hoffman-La Roche Inc.
Johnston George W.
Kulkosky Peter F.
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