Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Using tissue cell culture to make a protein or polypeptide
Patent
1995-06-06
1998-03-31
Horlick, Kenneth R.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Using tissue cell culture to make a protein or polypeptide
536 221, 536 235, 435325, 4352523, 4353201, C07H 2104
Patent
active
057337489
ABSTRACT:
Human colon specific gene polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polynucleotides or polypeptides as a diagnostic marker for colon cancer and as an agent to determine if colon cancer has metastasized. Also disclosed are antibodies specific to the colon specific gene polypeptides which may be used to target cancer cells and be used as part of a colon cancer vaccine. Methods of screening for agonists and antagonists for the polypeptide and therapeutic uses of the antagonists are disclosed.
REFERENCES:
Science, vol. 263, issued 18 Mar. 1994, Papadopoulos et al., "Mutation of a nutL Homolog in Hereditary Colon Cancer", pp. 1625-1629, see entire document.
The Journal of Biological Chemistry, vol. 269, No. 4, issued 28 Jan. 1994, Gum, Jr. et al, "Molecular Cloning of Human Intestinal Mucin (MUC2) cDNA", pp. 2440-2446, see entire document.
The Journal of Biological Chemistry, vol. 267, No. 30, issued 25 Oct. 1992, Gum, Jr. et al, "The Human MUC2 Intestinal Mucin Has Cysteine-rich Subdomains located Both Upstream and Downstream of its Central Repetitive Region", pp. 21375-21383, see entire document.
Advances in Brief, TJU, 1025, Walnut Street, Suite 1112, Philadelphia, P.A., Moreno, et al., "Detection of Hematogenous Micrometastasis in Patients with Prostate Cancer", pp. 6110-6112.
The Journal of Biological Chemistry, vol. 267, No. 8, issued 15 Mar. 1992, Xu et al., "cDNA for the Carboxyl-terminal Region of a Rat Intestinal Mucin-like Peptide", pp. 5401-5407, see entire document.
Lowe et al. Structure and Methylation pattern of the gene encoding human carbonic anhydrant I Gene, 1990, 93, 277-283.
database : Swiss-prot32.
database : accession No. JQ0786; ACQ02817.
Rosen Craig
Yu Guo-Liang
Horlick Kenneth R.
Human Genome Sciences Inc.
Mullins J.G.
Olstein Elliot M.
Tung Joyce
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