Colon specific gene and protein

Details Colon specific gene and protein Colon specific gene and protein

1995-06-06

1999-01-19

Jones, W. Gary

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 243, 435 6, C07H 2102, C07H 2104, C12Q 168

Patent

active

058614940

ABSTRACT:
Human colon specific gene polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polynucleotides or polypeptides as a diagnostic marker for colon cancer and as an agent to determine if colon cancer has metastasized. Also disclosed are antibodies specific to the colon specific gene polypeptides which may be used to target cancer cells and be used as part of a colon cancer vaccine. Methods of screening for agonists and antagonists for the polypeptide and therapeutic uses of the antagonists are also disclosed.

REFERENCES:
patent: 4683202 (1987-07-01), Mullis
patent: 5380645 (1995-01-01), Vogelstein
The New England Biolabs Catalog 1993-94 Edition pp. 92-95.
Nicolaides et al. Nature 371:75-80(1994).
PCT International Search Report.
Carcinogenesis, vol. 15, No. 7, pp. 1317-1323 (Jul. 1994).
Gastroenterology, vol. 104, No. 4, pp. 911-917 (Apr. 1993).
Cancer Supplement, vol. 70, No. 6, pp. 1732-1739 (Sep. 15, 1992).
Cancer Research, vol. 54, No. 23, pp. 6160-6166 (Dec. 1, 1994).

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