Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1995-04-17
1996-10-29
Low, Christopher S. F.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
536 231, 536 232, 536 2431, 4353201, 4351723, 4352402, 4352523, 935 4, 935 9, 935 6, 935 11, 930DIG530, C12N 1512, C12N 1511, C07K 14435
Patent
active
055697550
ABSTRACT:
A new down-regulated gene called DRA, for down regulated in adenoma, maps to chromosome 7 and is believed to encode a tumor suppressor. The DRA gene encodes a highly hydrophobic protein with charged clusters located primarily in the carboxyl terminus. Additionally, the expression of the mRNA product appears to be strictly limited to the mucosa of normal colon and it is down-regulated early in colon tumorigenesis. Absence of the DRA polypeptide in tissue that usually expresses it can be used as an indicator of tissue abnormality. The DRA gene and cDNA may also have therapeutic capabilities as well.
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Papas Takis S.
Schweinfest Clifford W.
Low Christopher S. F.
The United States of America as represented by the Department of
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