Colon cleansing compositions and methods

Details Colon cleansing compositions and methods Colon cleansing compositions and methods

2007-01-30

2007-01-30

Marschel, Ardin H. (Department: 1614)

Drug, bio-affecting and body treating compositions

Digestive system regulator containing solid synthetic...

Reexamination Certificate

active

10693328

ABSTRACT:
A composition comprising, per liter of aqueous solution, from 30 to 350 g polyethylene glycol, from 3 to 20 g of an ascorbic acid component selected form the group consisting of ascorbic acid, a salt of ascorbic acid, or a mixture thereof, an alkali metal or alkaline earth metal sulphate, preferably from 1 to 15 g thereof, and optionally one or more electrolytes selected from sodium chloride, potassium chloride, and sodium hydrogen carbonate, and preferably also comprising flavorings, is effective in cleansing the gut in preparation for a endoscopy, especially colonoscopy. It is safer than conventional sodium phosphate-based gut cleansing compositions, and hence can be used for patients who would be at risk with sodium phosphate-based compositions, and is better tolerated than conventional PEG-based compositions, leading to better patient compliance and enabling effective out-patient use.

REFERENCES:
patent: 5077048 (1991-12-01), Kimura et al.
patent: 5274001 (1993-12-01), Borody
patent: 5458890 (1995-10-01), Williford et al.
patent: 6048901 (2000-04-01), Cleveland et al.
patent: 6946149 (2005-09-01), Cleveland
patent: 0 436 061 (1993-05-01), None
patent: 0 397 689 (1994-05-01), None
patent: WO 87/00754 (1987-02-01), None
patent: WO 89/05659 (1989-06-01), None
patent: WO 03/037298 (2003-05-01), None
“Magnesium Sulfate”. Stedman's Medical Dictionary (Twenty-Second Edition). Williams and Wilkins Company, 1972. p. 737.
“Sodium Ascorbate”. Monograph 8723. The Merck Index (Twelfth Edition). Merck & Co., Inc. p. 1471.
“Structure Activity Relationship and Drug Design”. Remington's Pharmaceutical Sciences (Sixteenth Edition). Mack Publishing, 1980. pp. 420-425.
Andorsky et al., “Colonic Lavage Solution (Polyethylene Glycol Electrolyte Lavage Solution) as a Treatment for Chronic Constipation: A Double-Blind, Placebo-Controlled Study,”Am. J. Gastroenterol., 85(3):261-265, 1990.
Braintree Laboratories, GoLYTELY®, product information, Jun. 5, 2002.
Braintree Laboratories, NuLYTELY®, product information, Jun. 5, 2002.
Clarkston et al., “Oral Sodium Phosphate Versus Sulfate-Free Polyethylene Glycol Electrolyte Lavage Solution in Outpatient Preparation for Colonoscopy: A Prospective Comparison,”Gastrointestinal Endoscopy, 43(1):42-49, 1996.
Davis et al., “Development of a Lavage Solution Associated with Minimal Water and Electrolyte Absorption of Secretion,”Gastroenterology, 78(5):991-995, 1980.
Evesa, Neohesperidine Dihydrochaleone (NHDC), product information, Oct. 24, 2002.
FLEET Company, Fleet Phospho-soda, Prescribing information—Oral Saline Laxative, Jul. 29, 2002.
Fordtran et al., “A Low-Sodium Solution for Gastrointestinal Lavage,”Gastroenterology, 98:11-16, 1990.
Hammer et al., “Studies of Osmotic Diarrhea Induced in Normal Subjects by Ingestion of Polyethylene Glycol and Lactulose,”J. Clin. Invest., 84:1056-1062, 1989.
Ingebo and Heyman, “Polyethylene Glycol-Electrolyte Solution for Intestinal Clearance in Children with Refractory Encopresis,”Am. J. Dis. Child, 142:340-342, 1988.
Klean-Prep; Abstract 35 075, with translation.
LinTech, Contract Food Laboratory Service, Jul. 31, 2002.
Merolli, “Flavor Enhancement: Taking a Closer Look,”Food Product Design, Feb. 1997.
Movicol, Australian product information, Health Answers Australia Jul. 29, 2002.
Poon et al., “Two Liters of Polyethylene Glycol-Electrolyte Lavage Solution Versus Sodium Phosphate as Bowel Cleansing Regiment for Colonoscopy: A Prospective Randomized Controlled Trial,”Endoscopy, 23(7):560-563, 2002.
Puxty and Fox, “Golytely: A new Approach to Faecal Impaction in Old Age”,Age and Aging, 15:182-184, 1986.
Regev et al., “Comparison of Two Bowel Preparations for Colonscopy: Sodium Picosulphate with Magnesium Citrate Versus Sulphate-Free Polyethylene Glycol Lavage Solution,”Am. J. Gastroenterol., 93(9): 1478-1482, 1998.
Telstra, GLYCOPREP-C, Australian product information, Health Answers Australia, Jun. 5, 2002.
Thomas et al., “Patient Acceptance and Effectiveness of a Balanced Lavage Solution (Golytely) Versus the Standard Preparation for Colonoscopy,”Gastroenterology, 82:435-437, 1982.
Tolia, “Use of a Balanced Lavage Solution in the Treatment of Fecal Impaction,”J. Pediatr. Gastroenterol. Nutr., 7(2):299-301, 1988.
Ungerer & Company Manufactures of Fragrances, Flavor, Essential Oils, Aroma Chemicals, and Oleore, Jul. 31, 2002.

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