Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Particulate form
Reexamination Certificate
2007-06-05
2007-06-05
Tran, Susan (Department: 1615)
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Particulate form
C424S489000, C424S490000, C424S491000, C424S401000, C424S451000, C424S464000
Reexamination Certificate
active
10130783
ABSTRACT:
A suspension of vector particles (PV) based on polyamino acids and have a mean hydrodynamic diameter between 30 and 120 nm, and an insulin load factor of from 5 to 25% of associated insulin volume relative to the polyamino acid volume forming the vector particles. The polyamino acids are double-block polymers containing hydrophilic and hydrophobic monomers. The suspension may be prepared by copolymerizing N-carboxy anhydrides of hydrophobic monomers and precursors of hydrophilic monomers, in the presence of N-methyl pyrrolidone and methanol. The copolymer is optionally neutralized, subjected to dialysis, concentrated and water is eliminated to produce a solid powder, which can be suspended in a liquid to produce the colloidal suspension. Active principles such as insulin or vaccines are associated with the carrier particles to prepare special pharmaceutical products.
REFERENCES:
patent: 4351337 (1982-09-01), Sidman
patent: 4450150 (1984-05-01), Sidman
patent: 5286495 (1994-02-01), Batich et al.
patent: 5449513 (1995-09-01), Yokoyama et al.
patent: 5510103 (1996-04-01), Yokoyama et al.
patent: 5780579 (1998-07-01), Soula et al.
patent: 5904936 (1999-05-01), Huille et al.
patent: 6180141 (2001-01-01), Lemercier et al.
patent: 6630171 (2003-10-01), Huille et al.
patent: 2001/0000510 (2001-04-01), Sakurai et al.
patent: 0 583 955 (1994-02-01), None
patent: 0 734 720 (1996-03-01), None
patent: 0 721 776 (1996-07-01), None
patent: 2 746 035 (1997-09-01), None
patent: WO 88/01213 (1988-02-01), None
patent: WO 89/08449 (1989-09-01), None
patent: WO 91/06286 (1991-05-01), None
patent: WO 91/06287 (1991-05-01), None
patent: WO 9734584 (1996-03-01), None
patent: WO 96/29991 (1996-10-01), None
patent: WO 97/02810 (1997-01-01), None
patent: WO 97/34584 (1997-09-01), None
patent: WO 02/28521 (2002-04-01), None
Akiyoshi et al.,Stabilization of Insulin upon Supramolecular Complexation with Hydrophobized Polysaccharide Nanoparticle, Chemistry Letters (1995), vol. N8, pp. 707-708.
N. Bryson et al., copending U.S. Appl. No. 10/398,134, filed Apr. 1, 2003 (filed as PCT/FR01/03083).
S. Candau, Chapter 3 Light Scattering, inSurfactant Solutions, vol. 22, Ed. R. Zana, M. Dekker, Inc. New York (1984), pp. 147-207.
W.D. Fuller,A procedure for the facile synthesis of amino-acid N-carboxyanhydrides, Biopolymers (1976) vol. 15, pp. 1869-1871.
Harada et al.,Formation of Polyion Complex Micelles in an Aquous Milieu from a Pair of Oppositely-Charged Block Copolymers with Poly(Ethylene Glycol)Segments, Macromolecules, (1995) vol. 28, pp. 5294-5299.
M.J. Humphrey,Delivery System for Peptide Drugs, eds. S Davis et al., Plenum Press, N.Y. (1986), pp. 139-151.
Kataoka,Preparation of Novel Drug Carrier Based on the Self-Association of Block Copolymer, Drug Delivery Systems, (1995) vol. 10, p. 363-70.
Tsutsumiuchi et al.,Synthesis of Polyoxazoline—(Glyco)peptide Block Copolymer Ring-Opening Polymerization of(Sugar-Substituted)α Amino Acid N-Carboxyanhydrides with Polyoxazoline Macroinitiators, Macromolecules (1997) vol. 30, pp. 4013-4017.
Constancis et al. “Macromolecular Colloids of Diblock Poly(amino acids) That Bind Insulin” J. Colloid and Interface Sci. vol. 217, pp. 357-368 (1999).
Bryson Nathan
Touraud Franck
Flamel Technologies, Inc.
Patton & Boggs LLP
Tran Susan
LandOfFree
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