Colloid labelled with radionuclide and method

Details Colloid labelled with radionuclide and method Colloid labelled with radionuclide and method

1989-05-30

1990-11-13

Maples, John S.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

252634, 252635, A61K 4300

Patent

active

049700626

ABSTRACT:
A ferric hydroxide colloid having an alpha-emitting radionuclide essentially on the outer surfaces and a method of forming same. The method includes oxidizing a ferrous hydroxide to ferric hydroxide in the presence of a preselected radionuclide to form a colloid having the radionuclide on the outer surface thereof, and thereafter washing the colloid, and suspending the washed colloid in a suitable solution. The labelled colloid is useful in cancer therapy and for the treatment of inflamed joints.

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Szymendera et al., "Fate of Ferric Hydroxide Macroaggregates in the Lungs of Mice", J. Nuevear Medicine, vol. 15, No. 1, 1974.
Rauzen et al., "The Use of Ion Exchange + Electroplazmsis . . . ", Atomnaya Energiya, vol. 45, No. 1, Jul. 1978, pp. 49-53.
Rotmensch et al., "The Development of .alpha.--Emitting Radionuclide Lead 212", Am. J. Obstet. Gynecol., vol. 160, No. 4, Apr., 1989.

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