Chemistry: analytical and immunological testing – Clotting or clotting factor level tests
Patent
1985-02-25
1988-11-01
Richman, Barry S.
Chemistry: analytical and immunological testing
Clotting or clotting factor level tests
435 13, 436 18, G01N 3386, G01N 3300, C12Q 156
Patent
active
047820268
ABSTRACT:
An inhibitor of Platelet Factor 3 activity is included in a collection medium into which a whole blood sample is a collected. The inhibitor of Platelet Factor 3 activity, it has been discovered, prevents an initial drop in the activated clotting time measured during an assay test conducted on the whole blood sample collected in the medium. The discovery of the problem of the initial drop in the activated clotting time and the solution of including the inhibitor of Platelet Factor 3 activity is of considerable importance in heparin therapy, since the initial drop in the activated clotting time of heparinized blood is substantial. The inhibitor of Platelet Factor 3 activity can be included with a calcium chelating agent in the collection medium. Prostacylin and imidazole, which is an inhibitor of platelet thromboxane A2 synthesis, are effective inhibitors of Platelet Factor 3 activity.
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Baugh Robert F.
Taylor Cynthia A.
HemoTec, Inc.
Ley John R.
Richman Barry S.
Wallen T. J.
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