Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2007-05-01
2007-05-01
Foley, Shanon (Department: 1642)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C435S070100, C435S455000
Reexamination Certificate
active
11051328
ABSTRACT:
This invention provides a transcription unit which is isolated from the upstream nucleic acid sequence of the collapsing response mediator protein-1 (CRMP-1) gene, an invasion-suppressor gene. The transcription unit contains a nucleic acid regulatory sequence which demonstrates promoter and/or regulatory activities (such as providing a transcription factor binding site) to enhance the expression of the CRMP-1 and/or a reporter protein. The invention also provides a DNA construct containing this transcription unit which can be transfected into a host cell. Additionally, the invention provides methods to enhance the expression of CRMP-1 and/or the reporter protein. The over-expression of CRMP-1 in a cancer cell can inhibit the metastasis of the cancer cell.
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Chen Jeremy J. W.
Hong Tse-Ming
Lee Yi-Jen
Shin Jin-Yuan
Wu Cheng-Chung
Advpharma Inc.
Aeder Sean E
Andrews & Kurth LLP
Chao Fei-Fei
Foley Shanon
LandOfFree
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