Collagen wound healing matrices and process for their production

Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Matrices

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424422, 424 852, 424 854, 514 21, 514801, 514887, A61K 914

Patent

active

052195767

ABSTRACT:
Collagen implants that are useful as wound healing matrices are characterized by being formed of collagen fibrils that are not chemically cross-linked, and having a bulk density of 0.01 to 0.3 g/cm.sup.3 and a pore population in which at least about 80% of the pores have an average pore size of 35 to 250 microns. The implants are capable of promoting connective tissue deposition, angiogenesis, reepithelialization, and fibroplasia. The wound healing matrix also serves as an effective sustained delivery system for bioactive agents.

REFERENCES:
patent: 4950483 (1990-08-01), Ksander
patent: 4983580 (1991-01-01), Gibson
McPherson et al., Collagen and Related Research Clinical and Experimental (1988) 8(1):83-100.
Doillon et al., J. Biomed. Mater. Res. (1986) 20(8):1219-1228.

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