Collagen-thrombin compositions

Details Collagen-thrombin compositions Collagen-thrombin compositions

1983-11-16

1985-05-07

Morris, Theodore

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

Hydrolases

106124, 106161, 424 14, 514801, C08L 8906, A61K 3514, C08H 106

Patent

active

045156379

ABSTRACT:
A method of forming a collagen-thrombin hemostatic composition is comprised of forming a homogeneous aqueous admixture of collagen and thrombin at a basic pH and lyophilizing the collagen-thrombin admixture to form a stable collagen sponge having thrombin therein. The collagen utilized in the process is absorbable when placed in vivo. Additionally, a lyophilized collagen product is comprised of collagen which is absorbable when placed in vivo and thrombin distributed within the collagen. The collagen product is storage stable.

REFERENCES:
patent: 3928566 (1975-12-01), Briggs
patent: 4271070 (1981-06-01), Miyata et al.
patent: 4412947 (1983-11-01), Cioca
patent: 4414976 (1983-11-01), Schwarz et al.
patent: 4442655 (1984-04-01), Stroetmann
Derwent Abstract: South African Application No. 82/0123, Nov. 1982, Eberhard Zimmerman et al.

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