Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Matrices
Patent
1997-01-15
1999-02-02
Webman, Edward J.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Matrices
424 783, 525 541, 525 542, 527205, 530402, 530411, A61K 3839, A61K 910, A61K 4742, A61K 4736
Patent
active
058661654
ABSTRACT:
A matrix and a method for preparing it are provided to support the growth of bone or cartilage tissue. A polysaccharide is reacted with an oxidizing agent to open sugar rings on the polysaccharide to form aldehyde groups. The aldehyde groups are reacted to form covalent linkages to collagen.
REFERENCES:
patent: 4517295 (1985-05-01), Bracke et al.
patent: 4931546 (1990-06-01), Tardy et al.
patent: 5128326 (1992-07-01), Balazs et al.
Amiel, et al., 1985, "Rib Perichondrial Grafts for the Repair of Full-Thickness Articular-Cartilage Defects," J. Bone Joint Surg. 67A:911-920.
Blein-Sella, O., et al., 1995, "Rabbit Articular Chondrocyte Functional Toxicity Test," Methods Mol. Biol. 43:169-75.
Dietz, U., et al., 1993, "Alterations of Collagen mRNA Expression During Retinoic Acid Induced Chondrocyte Modulation: Absence of Untranslated .alpha.1(I) mRNA in Hyaline Chondrocytes," J. Cell Biol. 52(1):57-68.
Kuettner, K.E., et al. 1992, "Biochemistry of Articular Cartilage in Health and Disease," Clin. Biochem. 25:155-63.
Lee, M.K., et al., 1991, "Analysis of affinity and structural selectivity in the binding of proteins to glycosaminoglycans: Development of a sensitive electrophoretic approach," Proc. Natl. Acad. Sci. USA 88 (7):2768-72.
Sandell, L.J., et al., 1991, "Alternatively Spliced Type II Procollagen mRNAs Define Distinct Populations of Cells during Vertebral Development: Differential Expression of the AMino-Propeptide," J. Cell. Biol. 114 (4):1307-19.
Schmid, T.M., et al., 1985, "Immunohistochemical Localization of Short Chain Cartilage Collagen (Type X) in Avian Tissues," J. Cell Biol. 100:598-605.
Spiro, R.C., et al., 1991, "Uncoupling of Chondroitin Sulfate Glycosaminoglycan Synthesis by Brefeldin A," J. Cell. Biol., 115 (5):1463-73.
Thyberg and Moskalewski, 1979, "Bone Formation in Cartilage Produced by Transplanted Epiphyseal Chondrocytes," Cell Tissue Res. 204 (1): 77-94.
Wong and Cohn, 1975, "Target cells in bond for parathormone and calcitonin are different: Enrichment for each cell type by sequential digestion of mouse calvaria and selective adhesion to polymeric surfaces," Proc. Natl. Acad. Sci. USA 72:3167-71.
Liu Lin-Shu
Spiro Robert C.
Orquest, Inc.
Webman Edward J.
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