Collagen/polysaccharide bilayer matrix

Details Collagen/polysaccharide bilayer matrix Collagen/polysaccharide bilayer matrix

2005-08-30

2005-08-30

Wax, Robert A. (Department: 1653)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Matrices

C424S078300, C424S486000, C428S316600, C514S001000, C514S002600, C514S023000, C530S402000

Reexamination Certificate

active

06936276

ABSTRACT:
Disclosed are bilayer matrices of a polysaccharide such as collagen (COL) and another polysaccharide such as hyaluronic acid (HA) with various COL/HA ratios. Each layer has a porous structure. These materials are useful for tissue regeneration, particularly when used with orthopedic implants and drug delivery.

REFERENCES:
patent: 4784989 (1988-11-01), Hook et al.
patent: 4837285 (1989-06-01), Berg et al.
patent: 4841962 (1989-06-01), Berg et al.
patent: 4902289 (1990-02-01), Yannas
patent: 5157111 (1992-10-01), Pachence
patent: 5273900 (1993-12-01), Boyce
patent: 5489304 (1996-02-01), Orgill et al.
patent: 5573934 (1996-11-01), Hubbell et al.
patent: 5629191 (1997-05-01), Cahn
patent: 5833665 (1998-11-01), Bootman et al.
patent: 5837226 (1998-11-01), Jungherr et al.
patent: 5866165 (1999-02-01), Liu et al.
patent: 5906997 (1999-05-01), Schwartz et al.
patent: 5916585 (1999-06-01), Cook et al.
patent: 5972385 (1999-10-01), Liu et al.
patent: 5997895 (1999-12-01), Narotam et al.
patent: 6071447 (2000-06-01), Bootman et al.
patent: 6080194 (2000-06-01), Pachence et al.
patent: WO 97/06837 (1997-02-01), None
patent: WO 99/13902 (1999-03-01), None
International Search Report, International Application No. PCT/US/96/13244 (WO 97/06837).
International Search Report, International Application No. PCT/US/98/18849 (WO 99/13902).
Liu, L.-S., et al., “Local sustained release of growth factors from an implantable chondroitin sulfate scaffold for tissue regeneration,” Controlled Release Bioact. Mater., vol. 24, pp. 577-578, 1997.
Spiro, R.C., et al., “Inductive activity of recombinant human growth and differentiation factor-5,”Biochemical Society Transactions, vol. 28, Part 4, pp. 362-368, 2000.
Block, J.E., et al., “Does xenogenic demineralized bone matrix have clinical utility as a bone graft substitute?,” Medical Hypotheses, vol. 45, pp. 27-32, 1995.
Vonau, R.L., et al., “Combination of growth factors inhibits bone ingrowth in the bone harvest chamber,” Clinical Orthopaedics and Related Research, No. 386, pp. 243-251, May 2001.
Liu, L.-S., et al., The bioactivity and stability of bFGF in a novel hyaluronate/heparin conjugate. Proceed. Int'l. Symp. Control. Release Bioact. Mater., vol. 26, pp. 1024-1025, Jul. 1999.
Liu, L.-S., et al., “An osteoconductive collagen/hyaluronate matrix for bone regeneration,”Biomaterials, vol. 20, pp. 1097-1108, 1999.
Radomsky, M.L., et al., “Novel formulation of fibroblast growth factor-2 in a hyaluronan gel accelerates fracture healing in nonhuman primates,” Journal of Orthopaedic Research, vol. 17, No. 4, pp. 607-614, 1999.
Tay, B., et al., “Use of a collagen-hydroxyapatite matrix in spinal fusion, a rabbit model,” Spine, vol. 23, No. 21, pp. 2276-2281, 1998.
Liu, L.-S., et al., “Hyaluronate derivatives-based matrices for growth factor delivery and tissue regeneration,” Proc. Int'l. Symposium on Controlled Release of Bioactive Materials, vol. 25, pp. 996-997, Jun. 1998.

Affiliated with

Also associated with

Rating

Collagen/polysaccharide bilayer matrix does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Collagen/polysaccharide bilayer matrix, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Collagen/polysaccharide bilayer matrix will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3500371