Collagen-polymer conjugates

Details Collagen-polymer conjugates Collagen-polymer conjugates

1992-07-30

1994-07-12

Nutter, Nathan M.

Synthetic resins or natural rubbers -- part of the class 520 ser

Synthetic resins

Mixing of two or more solid polymers; mixing of solid...

523113, 523115, 424422, 424423, 424426, C08G 6348, A61F 1300, A61F 200

Patent

active

053289552

ABSTRACT:
Pharmaceutically acceptable, non-immunogenic compositions are formed by covalently binding atelopeptide collagen to pharmaceutically pure, synthetic, hydrophilic polymers via specific types of chemical bonds to provide collagen/polymer conjugates. The atelopeptide collagen can be type I, type II or type III and may be fibrillar or non-fibrillar. The synthetic hydrophilic polymer may be polyethylene glycol and derivatives thereof having a weight average molecular weight over a range of from about 100 to about 20,000. The compositions may include other components such as liquid, pharmaceutically acceptable, carriers to form injectable formulations, and/or biologically active proteins such as growth factors. The collagen-polymer conjugates of the invention generally contain large amounts of water when formed. The conjugates can be dehydrated to form a relatively solid object. The dehydrated, solid object can be ground into particles which can be suspended in a non-aqueous fluid such as an oil and injected into a living being for the purpose of providing soft tissue augmentation. Once in place, the particles rehydrate and expand in size five fold or more.

REFERENCES:
patent: 3619371 (1971-11-01), Crook et al.
patent: 3788948 (1974-01-01), Kagedal et al.
patent: 3876501 (1975-04-01), Hanushewsky
patent: 3949073 (1976-04-01), Daniels et al.
patent: 3960830 (1976-06-01), Bayer et al.
patent: 4002531 (1977-01-01), Royer
patent: 4055635 (1977-10-01), Green et al.
patent: 4088538 (1978-05-01), Schneider
patent: 4179337 (1979-12-01), Davis
patent: 4192021 (1980-03-01), Deibig et al.
patent: 4261973 (1981-04-01), Lee et al.
patent: 4301144 (1981-11-01), Iwashita et al.
patent: 4314380 (1982-02-01), Miyata et al.
patent: 4357274 (1982-11-01), Werner
patent: 4412989 (1983-11-01), Iwashita et al.
patent: 4414147 (1983-11-01), Klibanov et al.
patent: 4415665 (1983-11-01), Mosbach et al.
patent: 4424208 (1984-01-01), Wallace et al.
patent: 4451568 (1984-05-01), Schneider et al.
patent: 4488911 (1984-12-01), Luck et al.
patent: 4495285 (1985-01-01), Shimizu et al.
patent: 4496689 (1985-01-01), Mitra
patent: 4557764 (1985-12-01), Chu
patent: 4563350 (1986-01-01), Nathan et al.
patent: 4563490 (1986-01-01), Stol et al.
patent: 4582640 (1986-04-01), Smestad et al.
patent: 4592864 (1986-06-01), Miyata et al.
patent: 4642117 (1987-02-01), Nguyen et al.
patent: 4678468 (1987-07-01), Hiroyoshi
patent: 4687820 (1987-08-01), Hou et al.
patent: 4689399 (1987-08-01), Chu
patent: 4732863 (1988-03-01), Tomasi et al.
patent: 4737544 (1988-04-01), McCain et al.
patent: 4745180 (1988-05-01), Moreland et al.
patent: 4766106 (1988-08-01), Katre et al.
patent: 4828563 (1989-05-01), Muller-Lierhern
patent: 4847325 (1989-07-01), Shadle et al.
patent: 4935465 (1990-06-01), Garman
patent: 4979959 (1990-12-01), Guire
patent: 5162430 (1992-11-01), Rhee et al.
patent: 5201764 (1993-04-01), Kelman et al.
Chuapil et al. "Some Chemical and Biological Characteristics of a New Collagen-Polymer Compound Material" J. Biomed Mater. Res. vol. 3, pp. 315-322 (1969).
R. H. L. Chen et al., Properties of Two Urate Oxidases Modified by the Covalent Attachment of Poly(ethylene Glycol), Biochim Biophys Acta (1981) 660:293-98.
Davis et al., "Hypouricaemic Effect of Polyethyleneglycol Modified Urate Oxidase," Lancet (1981) 2:281-83.
P. S. Pyatak et al., "Preparation of a Polyethylene Glycol: Superoxide Dismutase Adduct, and an Examination of its Blood Circulating Life and Anti-Inflammatory Activity," Res Com Chem Path Pharmacol (1980) 29:113-27.
K. J. Wieder et al., "Some Properties of Polyethylene Glycol: Phenylalanine Ammonia-Lyase Adducts," J Biol Chem (1979) 254:12579-87.
K. V. Savoca et al., "Preparation of a Non-immunogenic Arginase by the Covalent Attachment of Polyethylene Glycol," Biochim Biophys Acta (1979) 578:47-53.
Lloyd et al. "Coupling of acrylic polymer and collagen by use of a water-soluble Carbodimide" J. Polymer Sci. Chem Ed. (1979) 17:3473-3483.
A. T. Viau et al. "Safety Evaluation of Free Radical Scavengers PEG-Catalase and PEG-Superoxide Dismutase," J Free Rad in Bio & Med (1986) 2:283-288.
A. T. Viau et al. "Toxicologic studies of a conjugate of asparaginase and polyethylene glycol in mice, rats, and dogs," Am J Vet Res (1986) 47:1398-401.
Nishida et al., "Hypouricaemic effect after oral administration in chickens of polyethlene glycol-modified uricase entrapped in liposomes," J Pharm Pharmacol (1984) 36:354-55.
Inada et al., "Ester Synthesis Catalyzed by Polyethylene Glycol-Modified Lipase in Benzene," Boichem & Biophys Res Comm (1984) 122:845-50.
Takahashi et al., "A Chemical Modification to Make Horseradish Peroxidase Soluble and Active in Benzene," Biochem & Biophys Res Comm (1984) 121:261-65.
Abuchowski et al., "Cancer Therapy with Chemically Modified Enzymes. I. Antitumor Properties of Polyethylene Glycol-Asparaginase Conjugates," Cancer Biochem Biophys (1984) 7:175-86.
J. A. M. Ramshaw et al., "Precipitation of Collagens by Polyethlene Glycols," Anal Biochem (1984) 141:361-65.
A. Bendich et al., "Immunological effects of native and polyethylene glycol-modified asparaginases from Vibrio succinogenes and Escherichia coli in normal and tumour-bearing mice," Clin Exp Immunol (1982) 48:273-78.

Affiliated with

Also associated with

Rating

Collagen-polymer conjugates does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Collagen-polymer conjugates, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Collagen-polymer conjugates will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-397014