Collagen mimetic and method of treating rheumatoid arthritis usi

Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Food or edible as carrier for pharmaceutical

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424464, 424489, 424548, 514 15, 514825, A61K 914, A61K 920, A61K 3808, A61K 3532

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active

058493239

ABSTRACT:
A collagen mimetic peptide having the nine amino acid sequence glycine-proline-hydroxyproline-glycine -proline-glutamine-glycine-methionine-glycine, and analogs thereof is described. The collagen mimetic peptide may be included within a pharmaceutical composition also containing a pharmaceutically acceptable carrier and/or animal tissue. The collagen mimetic peptide is used in a treatment of rheumatoid arthritis by orally administering the collagen mimetic in an amount effective to reduce or alleviate one or more symptoms associated with rheumatoid arthritis.

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patent: 5529786 (1996-06-01), Moore
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Kakimoto et al., "The Effect of Anti-adhesion Molecule Antibody on the Development of Collagen-Induced Arthritis", Cellular Immunology 142, pp. 326-337 (1992).
Bakker et al., "Experimental Immune Mediated Arthritis in Rhesus Monkeys: A Model for Human Rhesus Monkeys", Rheumatology International, pp. 21-29 (1990).
Ahmed, "Immune Cocktail, Anyone", Journal of Longevity Reseach, vol. 1/No. 7, pp. 6-7 (1995).
Sieper et al., "Oral Type II Collagen Treatment in Early Eheumatoid Arthritis", Arthritis & Rheumatism, vol. 39, No. 1, pp. 41-51 (Jan. 1996).
Trentham et al., "Effects of Oral Adminstration of Type II Collagen on Rheumatoid Arthritis", Science, vol. 261, (24 Sep. 1993).
Alberts et al., "Cell Junctions, Cell Adhesion, and the Extracelluar Matrix", Biology of the Cell, vol. 1, Chapter 19, pp. 978-986 (1994).

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