Collagen-induced platelet aggregation inhibitor

Details Collagen-induced platelet aggregation inhibitor Collagen-induced platelet aggregation inhibitor

1995-06-05

1998-03-03

Wax, Robert A.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

4352523, 4353201, 435325, 536 235, C12P 2106, C12N 1500, C12N 500, C07H 2104

Patent

active

057233128

ABSTRACT:
The invention provides a protein which inhibits collagen-induced platelet aggregation, derived from Triatoma pallidipennis, and derivatives thereof. The protein is useful for inhibition of collagen-induced human platelet aggregation or of cancer with metastatic tumor cells.

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Smith, et al., Thrombosis and Hemostasis, 65:678 (1991).
Munro, et al., Blood Coagulation and Fibrinolysis, 2:179-184 (1991).
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Gasic, et al., Biological Abstracts, vol. 76, Abstract No. 42969 (1983).
Connolly, et al., J. of Biol. Chem., 267(10):6893-6898 (Apr. 5, 1992).
Kellet, et al., J. of Biol. Chem., 267(10):6899-6904 (Apr. 5, 1992).
International Search Report dated Nov. 26, 1992.

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