Collagen-enzyme conjugates that exhibit no inflammatory response

Details Collagen-enzyme conjugates that exhibit no inflammatory response Collagen-enzyme conjugates that exhibit no inflammatory response

1982-01-12

1983-10-11

Schain, Howard E.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Stablizing an enzyme by forming a mixture, an adduct or a...

2601237, C12N 996

Patent

active

044093322

ABSTRACT:
Collagen polymers are rendered non-inflammatory by complexation with alkaline phosphatase according to the procedure disclosed. Applications of these non-inflammatory collagen complexes include the production of non-inflammatory collagen sutures, collagen soft tissue replacements including wound and burn coverings and arterial vessel replacements, collagen drug delivery devices, and vitreous replacement for opthalmologic therapy. Gels composed of the collagen-alkaline phosphatase conjugate plus calcium hydroxide are useful as an agent in endodontic therapy. Structural durability and stabilization of the anti-inflammatory properties of the material are enhanced by crosslinking with glutaraldehyde or other crosslinking agents. Glutaraldehyde also acts to sterilize and disinfect the collagen conjugate prior to in-vivo use.

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