Collagen density and structural change measurement and...

Details Collagen density and structural change measurement and... Collagen density and structural change measurement and...

2007-01-19

2011-11-01

Chen, Tse (Department: 3777)

Surgery

Diagnostic testing

Detecting nuclear, electromagnetic, or ultrasonic radiation

Reexamination Certificate

active

08047990

ABSTRACT:
A method and system for two and three dimensional mapping of tissue density and/or structural changes from image data and/or spatial reflected or transmitted signal maps, and correlating the maps to changes in collagen density. The method and system includes the steps of: receiving an image or spatial maps of acoustic-derived RF signal data from tissue comprised of multiple pixels, segregating the image into groups of pixels, each group of pixels having characteristics within a defined class, establishing a baseline set of classes corresponding to initial conditions of the imaged/mapped tissue, measuring a differential in the set of classes for a group of pixels, the differential corresponding to a change in pixel values for the group of pixels, correlating said measured differential to a density change for the tissue corresponding to the group of pixels, and overlaying an indication of collagen density over the tissue image or mapped signal responses correlated with thermal dose indicating a change in collagen density for the tissue.

REFERENCES:
patent: 6067371 (2000-05-01), Gouge et al.
patent: 6500121 (2002-12-01), Slayton et al.
patent: 7229411 (2007-06-01), Slayton et al.
patent: 2005/0209588 (2005-09-01), Larson et al.

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