Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Scleroproteins – e.g. – fibroin – elastin – silk – etc.
Patent
1998-05-27
1999-07-20
Tsang, Cecilia J.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Scleroproteins, e.g., fibroin, elastin, silk, etc.
530361, 530868, 514 2, 514 8, 514 21, 514885, 4241841, A61K 3817, A61K 3800
Patent
active
059257369
ABSTRACT:
The invention provides novel methods and compositions for the treatment of immune system-mediated arthritis, including rheumatoid arthritis. The subject compositions comprise one or more different types of collagen or collagen derivatives and a mucosa binding structure. Specific combinations of collagen and/or collagen derivatives may be used to treat specific types of arthritis. The collagen(s) and/or collagen(s) derivatives used in the subject compositions may be either obtained from natural sources or produced by recombinant genetic engineering techniques by chemical modification. Another aspect of the invention is to provide methods for treating various types of arthritis by administering an effective amount of the subject collagen-containing compositions. The methods of the invention involve the oral administration of a collagen or collagens found in a specific tissue, e.g., cartilage, so as to induce the suppression (immunological tolerance) of inflammation against the tissue from which the collagen is found to occur in nature. The methods of the invention include the administration of the subject collagen(s) and/or collagen derivative(s) containing compositions into the intestines so as to induce immune tolerance, e.g., oral administration.
REFERENCES:
patent: 5399347 (1995-03-01), Trentham et al.
"Fundamental Immunology," (Paul, W. ed.) 2d Ed., pp. 571-586, 600-605, 822-825 & 906, 1994.
Aichele et al., "Peptide-induced T-cell tolderance to prevent autoimmune diabetes in a transgenic mouse model" Proc. Nat. Acad. Sci. U.S.A. vol. 91, pp. 444-448 (1994).
Ayad et al., "Bovine Cartilage Types V and IX Collagens," Biochem. J. 262:753-761 (1989).
Boissier, et al., "Arthritogenicity of Minor Cartilage Collagens (Types IX and XI) In Mice," Arthritis & Rheumatism 33(1):1-8 (1990).
Charriere, et al., "Antibodies to Types I, II, IX and XI Collagen in the Serum of Patients with Rheumatic Diseases," Arthritis & Rheumatism 31(3):325-32 (1988).
Chiocchia et al., "T Cell Regulation of Collagen-Induced Arthritis in Mice," J. Immunol. 145(2):519-25 (1990).
Cremer et al., "Type XI Collagen-Induced Arthritis in the Lewis Rat," J. Immunol. 153(2):824-32, 1992.
Diab, "The Role of Type IX Collagen in Osteoarthritis and Rheumatoid Arthritis," Orthop. Rev. 22(2):165-70 (1993).
Duance et al., "Isolation and Characterization of the Precursor of Type M Collagen," Biochem. J. 221:885-889 (1984).
Grant et al., "The Structure and Synthesis of Cartilage Collagens," The Control of Tissue Damage, (Glauert A. ed.), pp. 3-28 (1988).
Krane et al., "Clinical Implications of Cartilage Metabolism in Arthritis," Eur. J. Rheumatol. Inflamm. 10(1):4-9 (1990).
Liu et al., "Chemical Abstracts," vol. 115, p. 679, Ref. No. 133025b (1991) (Oral Microbiol. Immunol. 6(1)1-5, (1991)).
Miller et al., "Preparation and Characterization of the Different Types of Collagen," Methods in Enz. 82:33-64 (1982).
Morgan et al., "Antibodies to Type II and XI Collagens: Evidence for the Formation of Antigen Specific as Well as Cross Reacting Antibodies in Patients with Rheumatoid Arthritis," Ann. Rheum. Dis. 47(12):1008-13 (1988).
Novotna, et al. "Contribution to the Mode of Action of Univalent Gold," J. Rheumatol. 50(2):93-98 (1991).
Thompson, et al. "Suppression of Collagen Induced Arthritis by Oral Administration of Type II Collagen: Changes in Immune and Arthritic Responses Mediated by Active Peripheral Suppression," Autoimmunity 16:189-199 (1993).
Trentham, et al. "Effects of Oral Administration of Type II Collagen on Rheumatoid Arthritis," Science 261:1727-1730 (1993).
Tish et al. "Antigen-specific immunotherapy: Is it a real possibility to combat T-cell-mediated autoimmunity?," Proc. Natl. Acad. Sci. U.S.A., 91:437-438 (1994).
Kivirikko Kari I.
Martin George
Neff Thomas
Piez Karl A.
Pihlajaniemi Taina
Fibrogen Inc.
Mohamed Adbel A.
Tsang Cecilia J.
LandOfFree
Collagen-based methods and formulations for the treatment of art does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Collagen-based methods and formulations for the treatment of art, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Collagen-based methods and formulations for the treatment of art will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1322772