Collagen-based matrices ribose cross-linked

Details Collagen-based matrices ribose cross-linked Collagen-based matrices ribose cross-linked

1988-11-23

1990-11-20

Lee, Lester L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530356, 604368, C07K 1520, C08L 8906

Patent

active

049719548

ABSTRACT:
Stabilized collagen-based matrices are prepared by non-enzymatic glycosylation of native collagen to irreversibly cross-link collagen polypeptide chains. The sugar cross-linking agents, preferably is D-ribose, provide non-immunogenic, non-toxic cross-linked collagen matrices especially useful in clinical and veterinary applications.

REFERENCES:
Lien et al., Science, 225, pp. 1489-1491 (Sep. 1984).
Fujimoto et al., Experientia 42(1986), 4 p. 405.
Kent et al., Biochem. J. 225(3), 745-752 (1985).

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