Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Matrices
Patent
1995-09-29
1998-09-15
Kishore, Gollamudi S.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Matrices
424422, 424424, 424426, 424485, 424486, 424487, 6048901, A61K 908
Patent
active
058075810
ABSTRACT:
Drugs are delivered in a sustained manner from an in vivo depot which is formed from a collagen-based injectable composition. The injectable composition is fluid when injected but undergoes crosslinking in situ to form a crosslinked collagen matrix which encloses the drug to be released. The composition also includes a flexible chain polymer which is similarly charged to the precrosslinked collagen. This flexible chain polymer is enclosed in the matrix as well when the matrix forms and alters the effective porosity of the matrix. The drug diffuses out of the matrix at a rate which depends upon the matrix's effective porosity.
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Berg Richard A.
Rosenblatt Joel S.
Collagen Corporation
Kishore Gollamudi S.
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