Cold menthol receptor-1 antagonists

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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Reexamination Certificate

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07897781

ABSTRACT:
The invention is directed to TRPM8 antagonists of Formula (I). More specifically, the present invention relates to certain novel compounds, methods for preparing compounds, compositions, intermediates and derivatives thereof and methods for treating TRPM8-mediated disorders. Pharmaceutical and veterinary compositions and methods of treating pain and various other disease states or conditions using compounds of the invention are also described.

REFERENCES:
patent: 2005/0176769 (2005-08-01), Hawkins et al.
patent: 10215321 (2003-10-01), None
patent: WO 00/12092 (2000-03-01), None
patent: WO 02/101045 (2002-12-01), None
patent: WO 2005/094569 (2005-10-01), None
patent: WO 2006/029142 (2006-03-01), None
patent: WO 2006/040103 (2006-04-01), None
patent: WO 2006/040136 (2006-04-01), None
patent: WO 2007/017092 (2007-02-01), None
patent: WO 2007/017093 (2007-02-01), None
patent: WO 2007/017094 (2007-02-01), None
PCT Search Report, PCT/US2007/068566, date of mailing Jan. 23, 2009.
Abe, J. et al.: “Ca2+-dependent PKC activation mediates menthol-induced desensitization of transient receptor potential M8”; Neuroscience Letters (2006) 397: 140-144.
Arbuzov, B.A.: “Reactions of trialkyl phosphates and dialkyl phosphonates with .alpha., Ibeta.-unsaturated carbonyl compounds”; Abstract, Chemical Abstracts Service, Columbus, Ohio, US (XP002456631) 1973.
Behrendt, H.J. et al.: “Characterization of the mouse cold-menthol receptor TRPM8 and vanilloid receptor type-1 VR1 using a fluorometric imaging plate reader (FLIPR) assay”; Br. J. of Pharmacology (2004) 141: 737-745.
Bennett, G.J. et al.: “A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man”; Pain (1988) 33(1): 87-107.
Bhatnagar, S. et al.: “Tramadol for Postoperative Shivering: A Double-Blind Comparison with Pethidine”; Anaesth Intensive Care (2001) 29(2): 149-154.
Bolser, D.C. et al.: “Pharmacological studies of allergic cough in the guinea pig”; European J. of Pharmacology (1995) 277: 159-164.
Braga, P.C.: “Destrorphan and Dextromethorphan: Comparative Antitussive Effects on Guinea Pigs”; Drugs Exper. Clin. Res. (1994) 20(5): 199-203.
Braw, Y. et al.: “Anxiety-like behaviors in pre-pubertal rats of the Flinders Sensitive Line (FSL) and Wistar-Kyoto (WKY) animal models of depression”; Behavioural Brain Research (2006) 167: 261-269.
Butler, S.H. et al.: “A limited arthritic model for chronic pain studies in the rat”; Pain (1992) 48: 73-81.
Collier, H.O.J. et al.: “The Abdominal Constriction Response and Its Suppression by Analgesic Drugs in the Mouse”; Br. J. Pharmacol. Chemother. (1968) 32(2): 295-310.
Cryan, J.F. et al.: “The Ascent of Mouse: Advances in Modelling Human Depression and Anxiety”; Nature Reviews Drug Discovery (Sep. 2005) 4(9): 775-790.
Defrin, R. et al.: “Characterization of chronic pain and somatosensory function in spinal cord injury subjects”; Pain (2001) 89: 253-263.
Defrin, R. et al.: “Sensory determinants of thermal pain”; Brain (2002) 125(Pt 3): 501-510.
Desmeules, J.A. et al.: “Neurophysiologic Evidence for a Central Sensitization in Patients With Fibromyalgia”; Arthritis & Rheumatism (May 2003) 48(5): 1420-1429.
El Mouedden, M. et al.: “Evaluation of pain-related behavior, bone destruction and effectiveness of fentanyl, sufentanil, and morphine in a murine model of cancer pain”, Pharmacology Biochem. and Behavior (2005) 82: 109-119.
Erichsen, H.K. et al.: “Comparative actions of the opioid analgesics morphine, methadone and codeine in rat models of peripheral and central neuropathic pain”; Pain (2005) 116: 347-358.
Finnerup, N.B., MD et al.: “Intravenous Lidocaine Relieves Spinal Cord Injury Pain”; Anesthesiology (2005) 102(5): 1023-1030.
Fox, A. et al.: “Critical evaluation of the streptozotocin model of painful diabetic neuropathy in the rat”; Pain (1999) 31: 307-316.
Ghilardi, J.R. et al.: “Selective Blockade of the Capsaicin Receptor TRPV1 Attenuates Bone Cancer Pain”; The J. of Neuroscience (Mar. 23, 2005) 25(12): 3126-3131.
Grahn, D.A. et al.: “Appropriate thermal manipulations eliminate tremors in rats recovering from halothane anesthesia”; J. Applied Physiology (1996) 81: 2547-2554.
Greenspan, J.D. et al.: “Allodynia in patients with post-stroke central pain (CPSP) studied by statistical quantitative sensory testing within individuals”; Pain (2004) 109: 357-366.
Hall, E. et al.: “Time-course of infection and responses in a coughing rat model of pertussis”; J Med. Microbiol. (1999) 48: 95-98.
Hallas, B., PhD et al.: Establishment of behavioral parameters for the evaluation of osteopathic treatment principles in a rat model of arthritis; J. Am. Osteopath Assoc. (1997) 97(4): 207-214.
Hirayama, Y. et al.: “Effect of FK3657, a non-peptide bradykinin B2receptor antagonist, on allergic airway disease models”; European J. of Pharmacology (2003) 467: 197-203.
Hunter, J.C. et al.: “The effect of novel anti-epileptic drugs in rat experimental models of acute and chronic pain”; European J. of Pharmacology (1997) 324: 153-160.
Iyengar, S. et al.: “Efficacy of Duloxetine, a Potent and Balanced Serotonin-Norepinephrine Reuptake Inhibitor in Persistent Pain Models in Rats”; The J. of Pharmacol. and Exper. Thera. (2004) 311(2): 576-584.
Jørum, E. et al.: “Cold allodynia and hyperalgesia in neuropathic pain: the effect ofN-methyl-D-aspartate (NMDA) receptor antagonist ketamine—a double-blind, cross-over comparison with alfentanil and placebo”; Pain (2003) 101: 229-235.
Kobayashi, K. et al.: “Distinct Expression of TRPM8, TRPA1, and TRPV1 mRNAs in Rat Primary Afferent Neurons with Aδ/C-Fibers and Colocalization with Trk Receptors”; The J. of Comparative Neurology (2005) 493: 596-606.
Koltzenburg, M. et al.: “Differential sensitivity of three experimental pain models in detecting the analgesic effects of transdermal fentanyl and buprenorphine”; Pain (2006) 126: 165-174.
Kozak, W. et al.: “Non-Prostaglandin Eicosanoids in Fever and Anapyrexia”; Frontiers in Bioscience (Sep. 1, 2004) 9: 3339-3355.
Kydonieus, A. et al.: “Elimination of Transdermal Drug-Induced Hypersensitivity by Topical Delivery of Ion Channel Modulating Agents”; Proceedings of the International Symposium on Controlled Release of Bioactive Materials (1997) 24th: 23-24.
Luger, N.M. et al.: “Efficacy of systemic morphine suggests a fundamental difference in the mechanisms that generate bone cancer vs. inflammatory pain”; Pain (2002) 99: 397-406.
Magyar, T. et al.: “Evaluation of vaccines for atrophic rhinitis—a comparison of three challenge models”; Vaccine (2002) 20: 1797-1802.
Mc Kemy, D.D. et al.: “Identification of a cold receptor reveals a general role for TRP channels in thermosensation”; Nature (Mar. 7, 2002) 416: 52-58.
Mc Murray, G. et al.: “Animal models in urological disease and sexual dysfunction”; British J. of Pharmacology (2006) 147: S62-S79.
Morin, C., PhD. et al.: “Disruption of Thermal Perception in a Multiple Sclerosis Patient With Central Pain”; The Clin. J. of Pain. (2002) 18(3): 191-195.
Motta, A.F. et al.: “The antinociceptive effect of iontophoretic direct application of diclofenac to arthritic knee-joints of rats”; Life Sciences (2003) 73: 1995-2004.
Mukerji, G. et al.: “Cool and menthol receptor TRPM8 in human urinary bladder disorders and clinical correlations”; BMC Urology (2006) 6:6.
Nagakura, Y. et al.: “Allodynia and Hyperalgesia in Adjuvant-Induced Arthritic Rats: Time Course of Progression and Efficacy of Analgesics”; The J. of Pharmacology and Exper. Therapeutics (2003) 306(2): 490-497.
Nikki, P. et al.: “Halothane-Induced H

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