Cold insoluble globulin, its purification and use

Details Cold insoluble globulin, its purification and use Cold insoluble globulin, its purification and use

1979-05-21

1982-02-16

Nucker, Christine M.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

Molecular bilayer structure

260112R, 260112B, 424 15, 424 9, A61K 4900, A61K 4300, C07G 700

Patent

active

043159060

ABSTRACT:
A highly purified, biologically active cold insoluble globulin (CIG) preparation is provided having specific opsonic activity of at least 1000 units per mg of CIG. Methods of purifying CIG using affinity antibody columns are described in which the biological activity of the purified CIG is greater than 95% of the activity of the starting material.
The purified CIG can be radiolabelled and radiopharmaceutical preparations containing such CIG are useful as scanning agents for in vivo localizing of areas where CIG-binding determinants are expressed. Such areas include thrombi and damaged tissue such as burns, heart, liver, spleen, muscle, skin, kidney and the like. These areas of localized radiolabelled CIG can be visualized with a gamma camera.

REFERENCES:
patent: 4198335 (1980-04-01), Collen
Saba et al., Surg. Annu., 7, 71-102, (1975).
Blumenstock et al., J. Biol. Chem., 253, 4287-4291, (1978).
Chen et al., Analyt. Biochem., 79, 144-151, (1977).
Kaplan et al., J. Reticuloendothel Soc., 15, 68a, (1974).
Kaplan et al., J. Reticuloendothel Soc., 20, 375-383, (1976).
Kishore et al., First Int. Symp. on Radiopharm. Chem., Sep. 21-24, 1976.

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