Cold-adapted equine influenza viruses

Details Cold-adapted equine influenza viruses Cold-adapted equine influenza viruses

2006-04-18

2006-04-18

Chen, Stacy B. (Department: 1648)

Chemistry: molecular biology and microbiology

Virus or bacteriophage, except for viral vector or...

C435S004000, C435S005000, C435S236000, C424S204100, C424S209100

Reexamination Certificate

active

07029903

ABSTRACT:
The present invention provides experimentally-generated cold-adapted equine influenza viruses, and reassortant influenza A viruses comprising at least one genome segment of such an equine influenza virus, wherein the equine influenza virus genome segment confers at least one identifying phenotype of the cold-adapted equine influenza virus, such as cold-adaptation, temperature sensitivity, dominant interference, or attenuation. Such viruses are formulated into therapeutic compositions to protect animals from diseases caused by influenza A viruses, and in particular, to protect horses from disease caused by equine influenza virus. The present invention also includes methods to protect animals from diseases caused by influenza A virus or other infectious agents utilizing the claimed therapeutic compositions. Such methods include using a therapeutic composition as a vaccine to generate a protective immune response in an animal prior to exposure to an infectious agent, as well as using a therapeutic composition as a treatment for an animal that has been recently infected with an infectious agent leading to respiratory disease, or is likely to be subsequently exposed to such an agent in a few days whereby the therapeutic composition reduces such respiratory disease, even in the absence of antibody-mediated immunity. The present invention also provides methods to produce cold-adapted equine influenza viruses, and reassortant influenza A viruses having at least one genome segment of an equine influenza virus generated by cold-adaptation.

REFERENCES:
patent: 3518347 (1970-06-01), Pavilanis et al.
patent: 3992522 (1976-11-01), Chanock et al.
patent: 4631191 (1986-12-01), Dale et al.
patent: 4683137 (1987-07-01), Coggins et al.
patent: 4693893 (1987-09-01), Campbell et al.
patent: 4920213 (1990-04-01), Dale et al.
patent: 5149531 (1992-09-01), Youngner et al.
patent: 5690937 (1997-11-01), Parkin et al.
patent: 6045790 (2000-04-01), Campbell
patent: 6177082 (2001-01-01), Dowling et al.
patent: 6436408 (2002-08-01), Dowling et al.
patent: WO83/03546 (1983-10-01), None
patent: WO 93/21310 (1993-10-01), None
patent: WO 00/09702 (2001-02-01), None
Brundage-Anguish, et al., 1982,Am J Vet Res, 43(5), pp. 869-874.
Enami, et al., 1990,PNAS, vol. 87, pp. 3802-3805.
Estola, et al., 1976,Nord Vet medvol. 28(7-8), pp. 353-356.
Hannant, et al., Feb. 6, 1988,Vet Rec, pp. 125-128.
Holmes, et al., 1992,Equine Infectious Diseases VI: Proceedings of the Sixth International Conference, Jul. 7-11, 1991 , pp. 253-258.
Ilobi, et al., 1998,Arch Virol, vol. 143, pp. 891-901.
Kucera, et al., 1977,Can J Comp Med, 41(3), pp. 326-331.
Mumford, et al., 1983,J Hyg(Lond), vol. 90(3), pp. 385-395.
Noble, et al., 1994,J Gen Virolvol. 75, pp. 3485-3491.
Reed, et al., 1938,The American Journal of Hygiene, vol. 27, pp. 493-497.
Timoney, P.J., 1996,Comp Immunol Microbiol Infect Dis, vol. 19(3), pp. 205-211.
USDA, 9 CFR 113.2XX, Oct. 28, 1994, Supplemental Assay Method for Conducting the Hemagglutination Inhibition Assay for Equine Influenza Antibody.
Van Maanen, et al., 1992,Vet Q, vol. 14(1), pp. 13-17.
Van Oirschot, et al., 1991,Zentralbl Veterinarmed [B ], vol. 38(5), pp. 391-396.
Wood, et al., 1983,J Hyg(Lond) vol. 90(3), pp. 371-384.
Wilson, et al., 1993,Vet Clin North Am Equine Practi, vol. 9(2), pp. 257-282.
Youngner, et al., 1994,J. of Clinical of Microbiology, vol. 32(3), pp. 750-754.
Lunn et al., 1999,Vaccine, vol. 17, pp. 2245-2258.
Romanova et al., 1997,Vaccine, vol. 15, No. 6/7, pp. 653-658.
Genetics of Influenza Viruses, edited by Peter Palese and David W. Kingsbury, 1983, by Springer-Verlag/Wien, New York.
Mayr, A., 1987,Tierärztl. Prax. Suppl., 2, 1-4, Abstract, XP-001015771 Abstract only.
Talon, et al., 2000,PNAS, vol. 97, No. 8, pp. 4309-4314.
Townsend, et al., 1999,AAEP Proceedings, vol. 45, pp. 41-42.

Affiliated with

Also associated with

Rating

Cold-adapted equine influenza viruses does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Cold-adapted equine influenza viruses, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Cold-adapted equine influenza viruses will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3529460