Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2006-04-04
2006-04-04
Saeed, Kamal A. (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C548S240000
Reexamination Certificate
active
07022724
ABSTRACT:
The present invention relates to compounds of formula I:in which R1is a linear group or a five membered heterocycle optionally fused to a phenyl ring, R2is a 5-membered heterocycle, R3is chosen from a range of substituents, m is 0–3 and n is 0 or 1; the compounds are generally inverse agonists at GABA-A receptors containing the alpha 5 subunit and so are useful in methods of enhancing cognition in subjects with diminished cognition in diseases such as Alzheimer's Disease.
REFERENCES:
Voitenko et al., Triazolo and tetrazoloisoindoles., Chemistry of Heterocyclic Compounds, 38(9), Sep. 2002, pp. 1019-1039.
FDA mulls drug to slow late-stage Alzheimer's [online], [retrieved on Sep. 23, 2003]. Retrieved from the Internet,URL;http://www.cnn.com/2003/HEALTH/conditions/09/24/alzheimers.drug.ap/index.html>.
Boase Amanda Louise
Ladduwahetty Tamara
MacLeod Angus Murray
Merchant Kevin John
Anderson Rebecca
Merck Sharp & Dohme Ltd.
Saeed Kamal A.
Todaro John C.
Winokur Melvin
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