Coenzyme Q.sub.10 with HMG-CoA reductase inhibitors

Details Coenzyme Q.sub.10 with HMG-CoA reductase inhibitors Coenzyme Q.sub.10 with HMG-CoA reductase inhibitors

1989-01-18

1990-06-12

Robinson, Douglas W.

Drug, bio-affecting and body treating compositions

Identification or warning feature

Taste or smell or chemical irritation to the eye, nose, or...

514415, 514460, 514510, 514689, A61K 31405, A61K 3135, A61K 3121, A61K 3112

Patent

active

049331655

ABSTRACT:
A pharmaceutical composition and method of counteracting HMG-CoA reductase inhibitor-associated myopathy is disclosed. The method comprises the adjunct administration of an effective amount of a HMG-CoA reductase inhibitor and an effective amount of Coenzyme Q.sub.10.

REFERENCES:
The New England Journal of Medicine, Scott M. Grundy 319 No. 1, pp. 24-33 Jul. 7, 1988.
Folkers et al, Proc. Natl. Acad. Sci., 82, 901(1985).
Folkers et al, Proc. Natl. Acad. Sci., 82, 4513(1985).
M. S. Brown & J. Goldstein, J. Lipid Res., 21, 505 (1980).
H. Mabuchi et al, N.E.J. Med., 478 (1981).

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