Coenzyme Q.sub.10 with HMG-CoA reductase inhibitors

Details Coenzyme Q.sub.10 with HMG-CoA reductase inhibitors Coenzyme Q.sub.10 with HMG-CoA reductase inhibitors

1989-02-02

1990-05-29

Robinson, Douglas W.

Drug, bio-affecting and body treating compositions

Identification or warning feature

Taste or smell or chemical irritation to the eye, nose, or...

514415, 514460, 514690, 514922, A61K 4500, A61K 31405, A61K 3135, A61K 3112

Patent

active

049294377

ABSTRACT:
A pharmaceutical composition and method of counteracting HMG-CoA reductase inhibitor-associated elevated transaminase levels is disclosed. The method comprises the adjunct administration of an effective amount of a HMG-CoA reductase inhibitor and an effective amount of Coenzyme Q.sub.10.

REFERENCES:
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patent: 4713397 (1987-12-01), Hirama et al.
Grundy, Scott M. (1988) New Eng. J. of Med 319(1):24-33 "HMG-CoA Reductase Inhibitors for Treatment of Hypercholesterolemia".
J. A. Tobert, Am. J. Cardiol., 1988, 62, 28J-34J.
M. S. Brown, J. Goldstein, J. Lipid Res., 21, 50S (1980).
J. S. MacDonald, Am J. Cardiol., 1988, 62, 16J-27J.
Effects of an Inhibitor of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase on Serum Lipoproteins . . . , H. Mabuchi, M.D. et al, New Eng. J. Med., 8/27/81.
Biochemical Rationale and Myocardial Tissue Data on the Effective Therapy of Cardiomyopathy with Coenzyme Q.sub.10, K. Folker et al., Proc. Natl. Acad. Sci. 82, pp. 901-904, Feb. 1985.
Biochemical Rationale and the Cardiac Response of Patients with Muscle Disease to Therapy with Coenzyme Q.sub.10, Proc. Natl. Acad. Sci., 82, pp. 4513-4516, Jul. 1985, K. Folkers et al.
Multivalent Feedback Regulation of HMG CoA Reductase, A Control Mechanism Coordinating Isoprenoid Synthesis and Cell Growth, J. Lipid Resarch, 21, pp. 505-517, 1980.

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