Chemistry: molecular biology and microbiology – Differentiated tissue or organ other than blood – per se – or... – Including perfusion; composition therefor
Patent
1998-05-20
2000-04-25
Saucier, Sandra E.
Chemistry: molecular biology and microbiology
Differentiated tissue or organ other than blood, per se, or...
Including perfusion; composition therefor
514675, A01N 100
Patent
active
060542616
ABSTRACT:
The present invention describes compositions and methods for use when an organ is isolated from the circulatory system, i.e., in organ transplantation and surgery. The composition of the present invention uses an organ preservation or perfusion solution to which is added a Coenzyme Q.sub.10 in a solubilizing agent. The solubilizing agent of the present invention is capable of solubilizing Coenzyme Q.sub.10, is non-toxic to organ tissues and cells, and is compatible with organ perfusion devices. When used in an organ perfusion the compositions of the Coenzyme Q.sub.10 does not precipitate from the compositions of the present invention. Particularly, the solubilizing agents are polysorbates, such as polysorbate-80 (polyoxyethzlene (20) sorbitan mono-oleate) or phosphatides, such as lecithin, and the like. Methods are also provided for using the compositions of the present invention to protect organs from free radical damage, ischemia and reperfusion injury during organ transplant and surgery.
REFERENCES:
Valls et al., "Potective Effect of Exogenous Coenzyme Q Against Damage by Adriamycin in Perfused Rat Liver", Biochemistry and Molecular Biology International 33 : 633-42 (1994).
Mori et al., "Effects of Coenzyme Q10 Added to a Potassium Cardioplegic Solution for Myocardial Protection during Ischemic Cardiac Arrest",Annals of Thoracic Surgery 39 : 30-6 (1985).
Yamamoto et al., "Potentiating Effect of Coenzyme Q on Root Potentials of Perfused Frog's Spinal Cord" Japan. J. Pharmacol. 22 : 707-14 (1972).
Handa et al., "Formation and Structure of Stably Dispersed Small Particles Composed of Phosphatidylcholine and Ubiquinone-10", J. Colloid Interface Sci. 143 : 205-13 (1991).
Kimura et al., "Factors Influencing the Tissue Distribution of Coenzyme Q10 Intravenously Administered in an Emulsion to Rats:Emulsifying Agents and Lipoprotein Lipase Activity" J. Pharm. Pharmacol. 38 : 659-62 (1986).
Julia et al., "Studies of controlled reperfusion after ischemia XXI" J. Thorac. Cardiovasc. Surg. 101 : 303-13 (1991).
Gunstone et al., The Lipid Handbook, second edition. Chapman & Hall, 1994, p. 99.
Q-pharma, Inc.
Saucier Sandra E.
LandOfFree
Coenzyme Q.sub.10 compositions for organ protection during perfu does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Coenzyme Q.sub.10 compositions for organ protection during perfu, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Coenzyme Q.sub.10 compositions for organ protection during perfu will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-992011