Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1997-02-12
1998-05-12
Huff, Sheela
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435 912, 435 911, 435 9121, 536 231, 536 235, 536 243, 536 2433, C12Q 168, C12P 1934, C07H 2104, C07H 2102
Patent
active
057504008
ABSTRACT:
This invention is directed to three coding sequences of the BRCA1 gene. The three coding sequences, BRCA1.sup.(omi1), BRCA1.sup.(omi2) and BRCA1.sup.(omi3) as well as their frequencies of occurrence are provided together with the protein sequences they code for. Another aspect of this invention is a method of determining the consensus sequence for any gene. Another aspect of the invention is a method of identifying an individual having an increased genetic susceptibility to breast or ovarian cancer because they have inherited a causative mutation in their BRCA1 gene. This invention is also related to a method of performing gene therapy with any of the isolated BRCA1 coding sequences.
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Allen Antonette C.
Alvares Christopher P.
Critz Brenda S.
Murphy Patricia D.
Olson Sheri J.
Gallegos R. Thomas
Halluin Albert P.
Huff Sheela
OncorMed, Inc.
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