Coding, promoter and regulator sequences of IRF-1

Details Coding, promoter and regulator sequences of IRF-1 Coding, promoter and regulator sequences of IRF-1

1994-11-18

1997-04-01

Elliott, George C.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

935 1, 935 3, 935 6, 935 33, 935 34, 935 36, 935 78, 435 911, C07H 2102, C07H 2104, C12N 1500, C12P 1934

Patent

active

056166990

ABSTRACT:
A recombinant DNA molecule coding for a protein having the activity of an interferon regulatory factor-1 (IRF-1).

REFERENCES:
Miyamoto, et al. Cell, vol. 54, 903-913 (1988).
Klemm, et al. "Ratsperm acrosin: cDNA sequence, derived primary structure and phylogenetic origin", Biochim. Biophys. Acta, 1090(2), 270-2, computer generated abstract & DNA polymer comparasins.
Fujita, T. et al., EMBO J. 7:3397-3405, "Evidence for a nuclear factor(s), IRF-1, mediating induction and silincing properties to human IFN-.beta. gene regulatory elements" (1988).
Miyamoto, M. et al., Cell 54:903-913, "Regulated Expression of a Gene Encoding a Nuclear Factor, IRF-1, That Specifically Binds to IFN-.beta. Gene Regulatory Elements" (1988).
Harada, H. et al., Cell 58:729-739, "Structurally Similar but Functionally Distinct Factors, IRF-1 and IRF-2, Bind to the Same Regulatory Elements of IFN and IFN-Inducible Genes" (1989).
Fujita et al., Nature 337:270-272, "Induction of endogenousIFN-.alpha. and IFN-.beta. genes by a regulatory transcription factor, IRF-1" (1989).
Harada, H. et al., Cell 63:303-312, "Absence of the Type I IFN System in EC Cells: Transcriptional Activator (IRF-1) and Repressor (IRF-2) Genes Are Developmentally Regulated" (1990).
Naf et al., Proc. Natl. Acad. Sci. USA 88:1369-1373, "Multimerization of AAGTGA and GAAAGT generates sequences that mediated virus inducibility by mimicking an interferon promoter element" (1991).
Au, W.-C. et al., Nucl. Acids Res. 20:2877-2884, "Distinct activation of murine interferon-.alpha. promoter region by IRF-1/ISFG-2 and virus infection" (1992).
Reis, L.F.L. et al., EMBO J. 11:85-193, "Critical role of a common transcription factor, IRF-1, in the regulation of IFN-.beta. and IFN-inducible genes" (1992).
Stark and Kerr, J. Interferon R. 12:147-151, "Interferon-Dependent Signaling Pathways: DNA Elements, Transcription Factors, Mutations, and Effects of Viral Proteins" (1992).
Watanabe, N. et al., Nucl. Acid Res. 19:4421-4428, "Activation of IFN-.beta. element by IRF-1 requires a post-translational event in addition to IRF-1 synthesis" (1991).
Yamada, G. et al., Proc. Natl. Acad. Sci. USA 88:532-536, "Specific depletion of the B-cell population induced by aberrant expression of human intrferon regulatory factor 1 gene in transgenic mice" (1991).
Keller, A.D. et al., Proc. Nat'l. Acad. Sci. USA 85:3309-3313 (1988).
Taniguchi, T., Ann. Rev. Immunol. 6:439-464 (1988).
Fujita, T. et al., Cell 41:489-496 (1985).
Dinter, H. et al., Eur. J. Biochem. 166:103-109 (1987).
Fujita, H. et al., Cell 49:357-367 (1987).
Levy, D.E. et al., Genes and Develop. 2:383-393 (1988).

Affiliated with

Also associated with

Rating

Coding, promoter and regulator sequences of IRF-1 does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Coding, promoter and regulator sequences of IRF-1, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Coding, promoter and regulator sequences of IRF-1 will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-540021