Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Chemical modification or the reaction product thereof – e.g.,...
Patent
1994-09-14
1997-02-25
Kim, Kay K. A.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Chemical modification or the reaction product thereof, e.g.,...
530317, 530324, 530325, 530326, 530327, 530328, 530329, 530330, 530408, 530409, 4241881, 4241941, 4241971, 4242081, C07K 1702, A61K 39385
Patent
active
056060300
ABSTRACT:
A novel coconjugate comprising an immunogenic protein or protein complex having a first set of covalent linkages to low molecular weight moieties, --a.sup.--, which have an anionic or polyanionic character at physiological pH, and a second set of covalent linkages to peptides comprising Human Immunodeficiency Virus (HIV) Principal Neutralizing Determinants (PNDs), or peptides immunologically equivalent therewith, is useful for inducing anti-peptide immune responses in mammals, for inducing HIV-neutralizing antibodies in mammals, for formulating vaccines to prevent HIV infection or disease, including the Acquired Immune Deficiency Syndrome (AIDS), or for treating humans afflicted with HIV infection or disease.
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Emini Emilio A.
Leanza William J.
Marburg Stephen
Tolman Richard L.
Giesser Joanne M.
Kim Kay K. A.
Merck & Co. , Inc.
Tribble Jack L.
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