Coccidiosis vaccines

Details Coccidiosis vaccines Coccidiosis vaccines

1981-09-08

1984-03-20

Wiseman, Thomas G.

Drug, bio-affecting and body treating compositions

Lymphokine

424 93, 435258, A61K 39012

Patent

active

044380976

ABSTRACT:
Attenuated E. necatrix suitable for use in the production of a live vaccine is produced by passaging pathogenic E. necatrix in embryonated eggs for a sufficient number of passages i.e. from about 20 up to about 50 or more egg passages. The live egg-attenuated E. necatrix of the invention may be formulated in vaccines, e.g. feed or drinking water vaccines, for prevention and control of coccidiosis in poultry, usually with other strains of Eimeria (i.e. E. acervulina, E. brunetti, E. maxima, E. mivali, E. praecose and E. tenella) as live pathogenic strains thereof or preferably attenuated non-pathogenic lines thereof. In a preferred embodiment the egg-attenuated E. necatrix of the invention is formulated in a vaccine comprising attenuated, precocious E. acervulina.

REFERENCES:
patent: 3029282 (1962-04-01), Toy et al.
patent: 3864394 (1975-02-01), Via et al.
patent: 4241021 (1980-12-01), Skrzec
T. A. Shibalova, vol. IX, pp. 299-303, (1972), "Acta Protozoologica".
P. L. Long, "The Growth of Eimeria in Cultured Cells and in Chicken Embryos" Symp. Proceedings, Ontario, (1974).
D. J. Doran, Journ. of Parasitology, vol. 57, No. 5, Oct. 1971, "Survival and Development of Five Species of Chicken Coccidia in Primary Chicken Kidney Cell Cultures".
P. L. Long, Parasitology, 56, pp. 575-581, (1966), "The Growth of Some Species of Eimeria in Avian Embryos".

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