Coccidiosis vaccine

Details Coccidiosis vaccine Coccidiosis vaccine

1984-06-29

1987-01-27

Hazel, Blondel

Drug, bio-affecting and body treating compositions

Lymphokine

530403, 514 2, A61K 39012, A61K 3700

Patent

active

046393722

ABSTRACT:
Sporozoites of coccidia fail to develop in chickens which are immune and many are blocked from penetrating host cells. Although previous attempts to immunize chickens with non-viable coccidial antigens have been unsuccessful it has been discovered that extracts from sporozoites or sporulated oocysts of E. tennella induce high levels of protective immunity. These extracts contain at least 15 polypeptides many of which are associated with the surface of the sporozoite and induce good immune responses. Antibody to these polypeptides blocks sporozoite-host cell penetration in vitro and neutralizes sporozoites in vivo. One or more of these polypeptides may be used as an antigen to protect against coccidiosis.

REFERENCES:
Statish, R. et al., J. Biol. Chem., vol. 251, pp. 302-307.
Rose et al., Symposium of the British Society for Porasitology, vol. 18, pp. 57-74, 1980.

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