Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant... – In an organic compound
Reexamination Certificate
2006-03-14
2006-03-14
Hartley, Michael (Department: 1618)
Drug, bio-affecting and body treating compositions
Radionuclide or intended radionuclide containing; adjuvant...
In an organic compound
C424S001810, C546S125000, C546S124000
Reexamination Certificate
active
07011813
ABSTRACT:
Tropane derivatives having a high binding affinity and selectivity for dopamine transporters bear, on the tropane backbone either a carboxylic ester or isoxazole moiety, as well as a substituted phenyl moiety. The compounds have utility both as pharmaceutical and as imaging agents, when one or more atoms are radioactive.
REFERENCES:
patent: 3813404 (1974-05-01), Clarke et al.
patent: 4111827 (1978-09-01), Thompson et al.
patent: 5116543 (1992-05-01), Lentsch
patent: 5128118 (1992-07-01), Carroll et al.
patent: 5186921 (1993-02-01), Kung et al.
patent: 5374636 (1994-12-01), Moldt et al.
patent: 5380848 (1995-01-01), Kuhar et al.
patent: 5413779 (1995-05-01), Kuhar et al.
patent: 5490955 (1996-02-01), Hagan et al.
patent: 5496953 (1996-03-01), Kuhar et al.
patent: 5554626 (1996-09-01), Moldt et al.
patent: 5736123 (1998-04-01), Carroll
patent: 5935953 (1999-08-01), Kuhar et al.
patent: 6123917 (2000-09-01), Carroll
patent: 6329520 (2001-12-01), Carroll et al.
patent: 6358492 (2002-03-01), Kuhar et al.
patent: 6531483 (2003-03-01), Kuhar et al.
patent: WO 93/09814 (1993-05-01), None
Reith et al., “Structural Requirements for Cocaine Congeners to Interact with Dopamine and Seratonin Uptake Sites in Mouse Brain and to Induce Stereotypical Behavior”, Biochemical Pharmacology, vol. 35, No. 7, pp. 1123-1129, 1986.
Boja, et al., “High Potency Cocaine Analogs: Neurochemical, Imaging, and Behavioral Studies”, The Neurobiology of Drug and Alcohol Addiction, vol. 654 of theAnnals of the New York Academy of SciencesJun. 28, 1992.
Balaster, et al., “Potent substituted-3β-phenltropane analogs of cocaine have cocaine-like discriminative stimulus effects”,Drug and Alcohol Dependence, 29 (1991) 145-151, Elsevier Scientific Publishers Ireland Ltd.
Cline, et al., “Stimulus generalization from cocaine to analogs with highin vitroaffinity for dopamine uptake sites”,Behavioural Pharmacology(1992).3 113-116 Short Report.
Cline, et al., “Behavioral Effects of Novel Cocaine Analogs: A Comparison within VivoReceptor Binding Potency”1,2, HE Journal of Pharmacology and Experimental Therapeutics, vol. 260, No. 3, 1992.
Australian Patent Office Examiner's first report received in corresponding application on Feb. 4, 2003.
F. Ivy Carroll, et al., Therapeutic Uses of nAChRs, Chemistry and Life Sciences, pp. 2-28, “Monoamine Transporter Binding, Locomotor Activity, and Drug Discrimination Properties of 3-(4-Substituted Phenyl)Tropane-2-Carboxylic Acid Methyl Ester Isomers”, Sep. 2004.
F. Ivy Carroll, et al., J. Med. Chem., 2004, 47, pp. 296-302, “Synthesis, Monoamine Transporter Binding Properties, and Behavioral Pharmacology of a Series of 3β-(Substituted phenyl)-2β-(3'-substituted isoxazol-5-yl)tropanes”.
Nida Res. Monogr. (MIDAD4, 03618595); 1990, vol. 96, “Drugs Abuse: Chem., Pharmacol., Immunol., AIDS”, pp. 112-121, XP002116828, Research Triangle Inst., Research Triangle Park, 27709, NC, USA.
F.I. Carroll, et al., “Synthesis and ligand binding of 3,β.-(3-subsituted phenyl)-and 3β-(3,4-disubstituted phenyl)tropane-2β-carboxylic acid methyl esters”, Med. Chem. Res. (McReeb, 10542523), 1991, vol. 1, No. 6, pp. 382-387, XP002116826, Research Triangle Inst., Research Triangle Park, 27709, NC, USA.
J. Med. Chem. (JMCMAR, 00222623), Mar. 20, 1992, vol. 35, No. 6, pp. 969-981, XP002116827, Research Triangle Inst., Research Triangle Park, 27709, NC, USA.
J. Med. Chem. (JMCMAR, 00222623), 1993, vol. 36, No. 20, pp. 2886-2890, XP002116829, Research Triangle Inst., Research Triangle Park, 27709, NC, USA.
P. Kotian, et al., J. Med. Chem., 1996, vol. 39, pp. 2753-2763, “Synthesis, Ligand Binding, and Quantitative Structure-Activity Relationship Study of 3β-(4'-Substituted phenyl)-2β-heterocyclic Tropanes: Evidence for an Electrostatic Interaction at the 2β-Position”.
F.I. Carroll, et al., J. Med. Chem., 2004, vol. 47, pp. 296-302, “Synthesis, Monoamine Transporter Binding Properties, and Behavioral Pharmacology of a Series of 3β-(Substituted phenyl)-2β-(3'substituted isoxazol-5-yl)tropanes”.
F.I. Carroll, et al., J. Med. Chem., 1995, vol. 38, pp. 379-388, “Cocaine and 3β-(4'-Substituted phenyl)tropane-2β-carboxylic Acid Ester and Amide Analogues. New High Affinity and Selective Compounds for the Dopamine Transporter”.
F.I. Carroll, et al., J. Med. Chem., 2004, 47, pp. 6401-6409, Monamine Transporter Binding, Locomotor Activity, and Drug Discrimination Properties of 3-(4-Substituted-phenyl)tropane-2-carboxylic Acid Methyl Ester Isomers.
Abraham Philip
Boja John W.
Carroll Frank Ivy
Kuhar Michael J.
Lewin Anita H.
Hartley Michael
Oblon & Spivak, McClelland, Maier & Neustadt P.C.
Research Triangle Institute
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