Cocaine and cocaine metabolites assay tracers, immunogens and an

Details Cocaine and cocaine metabolites assay tracers, immunogens and an Cocaine and cocaine metabolites assay tracers, immunogens and an

1990-08-30

1993-04-13

Ceperley, Mary E.

Chemistry: analytical and immunological testing

Involving immune complex formed in liquid phase

Signal modification or steric inhibition

436546, 436547, 436805, 436816, 436825, 5303898, 530405, 546126, 546129, 546130, G01N 33533, C07D45102, C07K 1300

Patent

active

052022706

ABSTRACT:
The present invention is directed to a fluorescence polarization assay for benzoyl ecgonine and substituted benzoyl ecgonine compounds in biological fluids, and to a method of making reagents therefor. Specifically, tracers, immunogens and antibodies are disclosed. The tracers and the immunogens are made from substituted benzoyl ecgonine compounds. A fluorescein moiety is included in the tracer, while a poly(amino acid) forms a part of the immunogen. The assay is conducted by measuring the degree of polarization retention of plane polarized light that has been passed through a sample containing antiserum and tracer.

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