Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1998-03-09
1998-11-10
Shah, Mukund J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
546124, 546132, A61K 3146, C07D45102
Patent
active
058344845
ABSTRACT:
Cocaine analogs are disclosed. The analogs, certain 6-alkyl substituted tropane derivatives, bind to the cocaine binding site on dopamine transporter, without interfering with the dopamine receptor. The craving for cocaine is thereby blocked. The analogs may readily be synthesized stereoselectively, and are relatively resistant to metabolic degradation.
REFERENCES:
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Z. Chen et al., "Synthesis of 6- or 7- Hydroxy and 6- or 7- Methoxy Tropanes," Tetrahedron Lett., vol. 38, pp. 1121-1124 (1997).
A. Kozikowski et al., "Dipolar Cycloaddition Route to Diverse Analogues of Cocaine: The 6- and 7- Substituted 3-Phenyltropanes," J. Org. Chem., vol. 62, pp. 503-509 (1997).
Lomenzo et al., "A Facile and Efficient Synthesis of (.+-.)-Tropan-2-one," Synthetic Communications, vol. 25, pp. 3681-3690 (1995).
Lomenzo Stacey A.
Trudell Mark L.
Board of Supervisors of Louisiana State University and Agricultu
Kessinger Ann M.
Runnels John H.
Shah Mukund J.
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