Cocaethylene immunogens and antibodies

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...

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530345, 530363, 435188, 436543, 436547, 540130, C07K 1600, A61K 3800, C07D45102

Patent

active

058177701

ABSTRACT:
The ethyl ester of derivatives of benzoyl ecgonine are provided having a linking group at the para position of the benzoyl group. The derivatives are used to bond to immunogenic polypeptides for production of antisera and monoclonal antibodies. The antisera and antibodies find use in assays, for treatment of cocaine overdose and detoxification.

REFERENCES:
patent: 5202270 (1993-04-01), Ungemach et al.
Jonathan Oyler et al., Journal of Analytical Toxicology, vol. 20, pp. 453-462, Oct. 1996.

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