Cobalamin assay

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C435S004000, C435S007500, C435S007900, C435S007920, C436S501000, C436S518000

Reexamination Certificate

active

09679043

ABSTRACT:
The invention provides an assay method for the determination of transcobalamin II (TC II) bound cobalamin in a body sample, comprising contacting a cell free sample of a body fluid with an immobilised or immobilizable specific binding ligand for TC II or cobalamin bound TC II (holo TC II), separating a ligand bound fraction from a non-ligand bound fraction and measuring the holo-TC II or TC-II bound cobalamin content therein.

REFERENCES:
patent: 4332785 (1982-06-01), Allen et al.
patent: 4465775 (1984-08-01), Houts
patent: 4680273 (1987-07-01), Herbert
patent: 5310656 (1994-05-01), Pourfarzaneh et al.
patent: 5374560 (1994-12-01), Allen et al.
patent: 5451508 (1995-09-01), Hoyle et al.
patent: 5506109 (1996-04-01), Pourfarzaneh et al.
Morelli et al., “Raioimmunoassay for serum transcobalamin II”, The Journal of Laboratory and Clinical Medicine, Mar. 1977, vol. 89, No. 3, pp. 645-652.
Maggio. Enzyme-Immunoassy. pp. 186-187, Copy write 1980 by CRC Press, Inc.
Edward T. Maggio, Enzyme-Immunoassay, pp. 186-187, copywrite 1980 by CRC Press, Inc.
Jacobsen et al. (Blood, vol. 55, No. 1, Jan. 1980, pp. 160-163).
Frater-Schroeder et al. (Analytical Biochemistry, 1982, vol. 124, No. 1, pp. 92-101, Abstract Only).
Steven C. Kuemmerle, et al., “Automated Assay of Vitamin B-12 by the Abbott IMx® Analyzer”, Clin. Chem. 38/10, 2073-2077 (1992).
Gary R. McLean et al., “Antibodies to Transcobalamin II Block in Vitro Proliferation of Leukemic Cells”, Blood, vol. 89, No. 1, Jan. 1, 1997, pp. 235-242.
Edward V. Quadros et al., “Characterization of Monoclonal Antibodies to Epitopes of Human Transcobalamin II”, Biochemical and Biophysical Research Communications 222, 149-154, (1996), Article No. 0713.
S.N. Wickramasinghe, S. Fida, “Correlations between holo-transcobalamin II, holo-haptocorrin, and total B12 in serum samples from healthy subjects and patients”, Department of Haematology, St. Mary's Hospital Medical School, J Clin Pathol 1993; 46:537-539.
Chemical Abstracts, Aug. 15, 1977, XP002127542 & E. Nexoe, “Characterization of the cobalamins attached to transcobalamin I and transcobalamin II in human plasma”, Scandinavian Journal of Haematology, 1977.
Chemical Abstracts, Jun. 3, 1996, XP002127543 & E.V. Quadros et al., “Characterization of monoclonal antibodies to epitopes of human transcobalamin II”, Biochemical and Biophysical Research Communications, 1996.
MEDLINE, Washington, D.C., XP002127541 & S.P. Rothenberg et al., “Transcobalamin II and the membrane receptor for the transcobalamin II-cobalamin complex”, Baillieres Clinical Haematology, 1995.
Paul A. Seligman and Robert H. Allen, “Characterization of the Receptor for Transcobalamin II Isolated from Human Placenta”, Sep. 6, 1977, Division of Hematology-Oncology, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63110 and the Division of Hematology, Department of Medicine, University of Colorado Medical Center, Denver CO 80262.
Victor Herbert et al., “Low Holotranscobalamin II is the Earliest Serum Marker for Subnormal Vitamin B12(Cobalamin) Absorption in Patients with AIDS”, 1990, Wiley-Liss, Inc. pp. 132-139.
Ebba Nexo et al., “How to Diagnose Cobalamin Deficiency”, Scand J. Clin Lab Invest 1994;54 (Suppl 219) pp. 61-75.
Haematology and Coagulation; XXIV Nordic Congress, Stockholm 1994, 44 “Haemoglobin A1con the Hitachi 717 Analyser”, A. Maki et al.; 45 “Measurement of TC-cobalamin, a marker of cobalamin deficiency”, Bodil Toft et al.; 46 “Quality goals for blood glycated hemoglobin A1c”, I.M. Penttila et al.; 47 “Serum transferring receptor is a new tool for diagnosis of iron deficiency anemia”, Kari Punnonen et al., pp. 62-63.
Ebba Nexo et al., “Characterization of the Particulate and Soluble Acceptor for Transcobalamin II from Human Placenta and Rabbit Liver”, Biochimica et Biophysica Acta, 628 (1980) 190-200.
Ebba Nexo, “Characterization of the Cobalamins Attached to Transcobalamin I and Transcobalamin II in Human Plasma”, Scand J. Haematol (1977) 18, 358-360.
Kuemmerle et al., “Automated Assay of Vitamin B12by the Abbott Imx® Analyzer”, Clin. Chem. 38/10, 2073-2077 (1992).
S.N. Wickramasinghe, S. Fida, “Correlations between holo-transcobalamin II, holo-haptocorrin, and total B12in serum samples from healthy subjects and patients”, J. Clin. Pathol 1993, 46 537-539.
Thu Vu et al., “New Assay for the Rapid Determination of Plasma Holotranscobalamin II Levels: Preliminary Evaluation in Cancer Patients”, American Journal of Hematology 42:202-211 (1993).
Barry Herzlich and Victor Herbert, “Depletion of Serum Holotranscobalamin II An Early Sign of Negative Vitamin B12Balance”, Laboratory Investigation, vol. 58, No. 3, pp. 332-337, 1988.
J. Lindemans et al., “Application of a simple immunoadsorption assay for the measurement of saturated and unsaturated transcobalamin II and R-binders”, Clinica Chimica Acta, 132 (1983) 53-61.
J. van Kapel et al., “Application of heparin-conjugated Sepharose for the measurement of cobalamin-saturated and unsaturated transcobalamin II”, Clinica Chimica Acra, 172 (1988) 297-310.
S. Benhayoun et al., “Method for the Direct Specific Measurement of Vitamin B12Bound to Tanscobalamin II in Plasma”, Acta Haematol 1993:89:195-199.
Edward V. Quadros et al., “Characterization of Monoclonal Antibodies to Epitopes of Human Transcobalamin II”, Biochemical and Biophysical Research Communiocations 22, 149-154 (1996), Article No. 0713.
Gary R. McLean et al., “Antibodies to Transcobalamin II Block in Vitro Proliferation of Leukemic Cells”, The American Society of Hematology, 1997, pp. 235-242.
Sheldon P. Rothenberg, Edward V. Quadros, “Transcobalamin II and the membrane receptor for the transcobalamin II-cobalamin complex”, B. Clinical Haematology, vol. 8, No. 3, Sep. 1995.
Soren K. Moestrup et al., “Megalin-mediated endocytosis of transcobalamin-vitamin-B12complexes suggests a role of the receptor in vitamin-B12homeostasis”, Proc. Natl. Acad. Sci. USA, vol. 93, pp. 8612-8617, Aug. 1996, Medical Sciences.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Cobalamin assay does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Cobalamin assay, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Cobalamin assay will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3885519

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.