Coating medical devices with cationic antibiotics

Details Coating medical devices with cationic antibiotics Coating medical devices with cationic antibiotics

1988-06-15

1990-01-23

Rosenbaum, C. Fred

Surgery

Means for introducing or removing material from body for...

Treating material introduced into or removed from body...

A61M 5325

Patent

active

048955663

ABSTRACT:
A medical device having long-lasting bactericidal properties and a method for making the same is provided. The material from which the medical device is made, the substrate, carries a negatively-charged group having a pKa of less than 6. A cationic antibiotic is ionically bonded to the negatively-charged group. The negatively-charged group may be a portion of a larger carrier molecule. The carrier molecule is bound to the substrate such that the negatively-charged group is exposed for ionic interaction with the cationic antibiotic. Heparin is an ideal carrier molecule because it has both anti-bacterial adhesion activity and anti-thrombogenic activity.

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Lubert Stryer, Biochemistry, 2nd Ed., published by: W. H. Freeman and Company 1981, pp. 180, 201.

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