Coating having biological activity and medical implant having su

Details Coating having biological activity and medical implant having su Coating having biological activity and medical implant having su

1999-08-30

2000-12-12

Beck, Shrive

Coating processes

Medical or dental purpose product; parts; subcombinations;...

Implantable permanent prosthesis

427 228, 427 23, A61L 2700, C08J 718, H05H 100, H05H 124

Patent

active

061595314

ABSTRACT:
A multi-step method for surface modification of a medical device having at least one surface exposed to tissue and/or blood. The steps comprise a low temperature plasma treatment of the said surface to provide a plasma deposited layer having functional groups. A chemical treatment of the plasma deposited layer using multifunctional linkers establishes covalent bonds with the plasma deposited layer. A bioactive/biocompatible agent react with the multifunctional linkers so that molecules thereof are covalently bound to said surface.

REFERENCES:
patent: 4656083 (1987-04-01), Hoffman et al.
patent: 5217492 (1993-06-01), Guire et al.
patent: 5591140 (1997-01-01), Narayanan et al.
patent: 5643580 (1997-07-01), Subramaniam
patent: 5866113 (1999-02-01), Hendriks et al.

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