Coating processes – Medical or dental purpose product; parts; subcombinations;... – Analysis – diagnosis – measuring – or testing product
Reexamination Certificate
2001-01-17
2001-07-17
Wu, David W. (Department: 1713)
Coating processes
Medical or dental purpose product; parts; subcombinations;...
Analysis, diagnosis, measuring, or testing product
C604S265000, C428S213000, C428S212000
Reexamination Certificate
active
06261630
ABSTRACT:
FIELD OF THE INVENTION
This invention relates to medical devices which have a segment which is inserted into the body and a segment which is retained outside the body for manipulation.
In particular, it relates to structures for which the in-the-body portion is a dilation balloon coated with a lubricious compound. Specifically, this invention relates to a method of coating a balloon which creates lubricity gradients on the balloon. The balloon is coated prior to being blown and the resultant balloon has different amounts of coating on the different parts of the balloon.
BACKGROUND OF THE INVENTION
Dilatation catheters are devices which have an inflatable balloon at the distal end and are utilized in medical procedures such as angioplasty to eliminate stenoses or blockages. The balloons are inserted into vessels in the body to open stenoses or blockages in the vascular system, usually by means of a catheter having a balloon at its distal end. To this end, the catheters may be inserted into a blood vessel, advanced through the blood vessel to a target site (i.e. the location of the stenosis or blockage) and the balloon is then inflated by supplying a liquid such as a radiopaque substance for angiography, through an inflation lumen. The inflation of the balloon causes stretching and expansion of the target site, i.e. a blood vessel, in order to eliminate the stenosis or blockage thereby reestablishing acceptable blood flow.
There are various types of catheters having single or multiple lumen, and some which are over-the-wire and some which are not. For the purpose of the present invention, all catheters will hereinafter be referred to as “balloon catheters.”
These devices need a certain degree of lubricity so as to avoid injury to tissues, mucous membranes and other bodily parts with which they come into contact during insertion into a blood vessel, for instance. Balloons are typically made of polymeric materials including nylon, Selar®, polyether-polyester block copolymers (e.g. Hytrel® or Arnitel®), poly(amide-ether-ester) block copolymers such as Pebax®, polyethylene terephthalate, polytetrafluoroethylene, polyvinyl chloride, polyurethanes, polyetherurethanes, polyesterurethanes, polyurethane ureas, polyurethane siloxane block copolymers, polyethylene, polypropylene or other similar extrudable thermoplastic, polymeric materials, or composites thereof. Such materials are typically inherently nonlubricious making it necessary to add some type of lubricious coating to the surface in order to advance the device through the blood vessel more easily.
However, once the balloon is at the target site, it will be necessary that it may be retained easily at the site during expansion or contraction without slippage. This is more readily accomplished when the balloon material has no lubricity.
Balloons will therefore typically have a lubricating portion and a non-lubricating portion to avoid what is referred to in the industry as the “watermelon seed” problem wherein a balloon which is too lubricious shoots forward on inflation causing accidental slippage from the target site. U.S. Pat. No. 5,503,631 to Onishi et al. discloses a vasodilating catheter balloon whose body has a lubricating portion and a non-lubricating portion. The lubricious property of the balloon is created by grafting a lubricious coating onto a non-lubricious substrate. Only the tapered portions on opposite ends of the balloon were treated.
The present inventors have now found a simplistic method for coating a balloon prior to formation of the balloon which achieves a lubricious coating gradient necessary for the successful use of a balloon catheter. The balloon exhibits superior retention at the target site without the “watermelon seed” effect, and exhibits excellent lubricity during insertion into the body cavity.
SUMMARY OF THE INVENTION
The present invention relates to a dilatation balloon formed from an extruded tubing by blowing. The balloon has a body, at least one cone and at least one waist portion and a lubricity coating gradient from the body portion which has the lowest coating thickness to the waist portion which has the highest coating thickness. The balloon material is first extruded into a tubular form prior to balloon formation which is accomplished by dry blowing the balloon material. The lubricious coating is applied to the extruded tubing prior to blowing the balloon. It is the different amounts of expansion which occur for the body, the cone and the waist which cause the lubricity gradient.
REFERENCES:
patent: 2814296 (1957-11-01), Everett
patent: 3566874 (1971-03-01), Shepherd
patent: 3826674 (1974-07-01), Schwarz
patent: 4026296 (1977-05-01), Stay et al.
patent: 4100309 (1978-07-01), Micklus et al.
patent: 4156066 (1979-05-01), Gould
patent: 4156067 (1979-05-01), Gould
patent: 4248685 (1981-02-01), Beede et al.
patent: 4373009 (1983-02-01), Winn
patent: 4447590 (1984-05-01), Szycher
patent: 4459317 (1984-07-01), Lambert
patent: 4459318 (1984-07-01), Hyans
patent: 4467073 (1984-08-01), Creasy
patent: 4490421 (1984-12-01), Levy
patent: 4588398 (1986-05-01), Daugherty et al.
patent: 4705709 (1987-11-01), Vailancourt
patent: 4863424 (1989-09-01), Blake, III et al.
patent: 4876126 (1989-10-01), Takemura et al.
patent: 4921483 (1990-05-01), Wijay et al.
patent: 4977901 (1990-12-01), Ofstead
patent: 4990357 (1991-02-01), Karakelle et al.
patent: 5026607 (1991-06-01), Kiezulas
patent: 5041100 (1991-08-01), Rowland et al.
patent: 5077352 (1991-12-01), Elton
patent: 5084315 (1992-01-01), Karimi et al.
patent: 5091205 (1992-02-01), Fan
patent: 5100381 (1992-03-01), Burns
patent: 5135516 (1992-08-01), Sahatjian et al.
patent: 5229211 (1993-07-01), Murayama et al.
patent: 5348538 (1994-09-01), Wang et al.
patent: 5441488 (1995-08-01), Shimura
patent: 5490839 (1996-02-01), Wang et al.
patent: 5503631 (1996-04-01), Onishi et al.
patent: 5509899 (1996-04-01), Fan et al.
patent: 5531715 (1996-07-01), Engelson et al.
patent: 5556383 (1996-09-01), Wang et al.
patent: 5587125 (1996-12-01), Roychowdhury
patent: 5670558 (1997-09-01), Onishi et al.
patent: 5693034 (1997-12-01), Buscemi et al.
patent: 5749837 (1998-05-01), Palermo et al.
patent: 5792415 (1998-08-01), Hijikema
patent: 5826588 (1998-10-01), Forman
patent: 5849209 (1998-12-01), Kindt-Larsen et al.
patent: 6046143 (2000-04-01), Khan et al.
patent: 6071266 (2000-06-01), Kelley
patent: 0 380 102 (1990-08-01), None
patent: 0 480 809 A2 (1992-04-01), None
patent: 0 519 604 A2 (1992-12-01), None
patent: 0 592 870 A1 (1994-04-01), None
patent: 0 693 293 (1996-01-01), None
patent: 91/08790 (1991-06-01), None
patent: 94/27665 (1994-12-01), None
patent: 98/55172 (1998-12-01), None
U.S. application no. 09/306,939, Nazarova et al., filed May 7, 1999, pending.
U.S. application no. 08/868,301, Wang et al., filed Jun. 3, 1997.
Gantrez® AN Copolymer pp. 1-13;1995.
M. Szycher, Blood Compatible Materials and Devices Perspectives Towards the 21st Century, C. P. Sharma and M. Szycher eds.
Graham, Neil B., “Poly(ethylene oxide) and Related Hydrogels”,Hydrogels in Medicine and Pharmacy, vol. II Polymers, Ed. by N.A. Peppa, CRC Press, Inc., Boca Raton Florida, 1986, pp. 95-113.
Nazarova Irina
Wang Lixiao
Lu Caixia
Sci-Med Life Systems, Inc.
Vidas Arrett & Steinkraus
Wu David W.
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