Coated vaginal device for delivery of anti-migraine and...

Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Implant or insert

Reexamination Certificate

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C424S430000, C424S432000

Reexamination Certificate

active

07744916

ABSTRACT:
A vaginal device for delivery of an anti-migraine or anti-nausea drug to the uterus and/or to the general circulation through vaginal mucosa. The device is at least partially coated with one or several layers of fluid impermeable material forming a cap, film, foam, foil or strip incorporated with mucoadhesive composition comprising the anti-migraine or anti-nausea drug.

REFERENCES:
patent: 6197327 (2001-03-01), Harrison et al.
patent: 2002/0055495 (2002-05-01), Jannetta
patent: 391852 (1990-10-01), None
Patrick Henry, et al., A Nationwide Survey of Migraine in France: Prevalence and Clinical Features in Adults,Cephalalgia, 12:229-237, (1992).
Lori A. Rokicki, PhD., et al., An Examination of the Validity of the IHS Classification System for Migraine and Tension-Type Headache in the College Student Population,Headache, 39:720-727, (1999).
Walter F. Stewart, PhD., MPH, et al., Prevalence of Migraine Headache in the United States, Relation to Age, Income, Race, and Other Sociodemographic Factors,JAMA, 267/1:64-69, (Jan. 1, 1992).
G.D. Solomon, et al., Burden of Migraine, a Review of its Socioeconomic Impact,Pharmacoeconomics, 11/1:1-10, (1997).
H. Vergin, et al., Analysis of Formulation and Food Effect on the Absorption of Metoclopramide,International Journal of Clinical Pharmacology and Therapeutics, 40/4:169-174, (2002).

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